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Transperineal laser ablation (TPLA) with ultrasound/MRI fusion guidance in the treatment of localized radiotherapy-resistant prostate cancer
OBJECTIVE: The objective of this study was to assess the technical feasibility, safety, and efficacy of transperineal laser ablation (TPLA) guided by ultrasound/magnetic resonance (MR) fusion as a salvage treatment for refractory focal prostate cancer. METHODS: A total of five patients who had under...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The British Institute of Radiology.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630978/ https://www.ncbi.nlm.nih.gov/pubmed/37942495 http://dx.doi.org/10.1259/bjro.20230042 |
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author | Manenti, Guglielmo Nezzo, Marco Ryan, Colleen Patricia Fraioli, Federico Romeo Carreri, Beatrice Gigliotti, Paola Elda Angeloni, Cecilia Di Pietro, Francesca De Angeli, Martina Perretta, Tommaso D'Angelillo, Rolando Maria Garaci, Francesco Giuseppe |
author_facet | Manenti, Guglielmo Nezzo, Marco Ryan, Colleen Patricia Fraioli, Federico Romeo Carreri, Beatrice Gigliotti, Paola Elda Angeloni, Cecilia Di Pietro, Francesca De Angeli, Martina Perretta, Tommaso D'Angelillo, Rolando Maria Garaci, Francesco Giuseppe |
author_sort | Manenti, Guglielmo |
collection | PubMed |
description | OBJECTIVE: The objective of this study was to assess the technical feasibility, safety, and efficacy of transperineal laser ablation (TPLA) guided by ultrasound/magnetic resonance (MR) fusion as a salvage treatment for refractory focal prostate cancer. METHODS: A total of five patients who had undergone radiation therapy (RT) for prostate carcinoma and biochemical recurrence, confirmed by both prostate-specific antigen (PSA) levels and MRI (3T mpMRI), were enrolled in this study. Focal ablation was performed using a 1064 nm diode laser. Post-ablation follow-up was conducted for a duration of 18 months, which included regular PSA sampling, 3T mpMRI, and ultrasound/MR fusion-guided biopsies systematic and targeted at the site of the focal treatment. RESULTS: The focal ablation procedure was carried out in an outpatient setting regimen with optimal clinical and biochemical outcomes. No recurrence was detected throughout the follow-up period. CONCLUSION: TPLA focal treatment effectively manages local recurrences of RT refractory prostate cancer without side-effects or complications. Preservation of quality of life and functional outcomes, along with a >70% reduction in PSA, were achieved. ADVANCES IN KNOWLEDGE: Our study investigated TPLA as a salvage treatment for low-risk recurrent prostate cancer after RT, demonstrating its tolerability, feasibility, and effectiveness. |
format | Online Article Text |
id | pubmed-10630978 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The British Institute of Radiology. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106309782023-11-07 Transperineal laser ablation (TPLA) with ultrasound/MRI fusion guidance in the treatment of localized radiotherapy-resistant prostate cancer Manenti, Guglielmo Nezzo, Marco Ryan, Colleen Patricia Fraioli, Federico Romeo Carreri, Beatrice Gigliotti, Paola Elda Angeloni, Cecilia Di Pietro, Francesca De Angeli, Martina Perretta, Tommaso D'Angelillo, Rolando Maria Garaci, Francesco Giuseppe BJR Open Original Research OBJECTIVE: The objective of this study was to assess the technical feasibility, safety, and efficacy of transperineal laser ablation (TPLA) guided by ultrasound/magnetic resonance (MR) fusion as a salvage treatment for refractory focal prostate cancer. METHODS: A total of five patients who had undergone radiation therapy (RT) for prostate carcinoma and biochemical recurrence, confirmed by both prostate-specific antigen (PSA) levels and MRI (3T mpMRI), were enrolled in this study. Focal ablation was performed using a 1064 nm diode laser. Post-ablation follow-up was conducted for a duration of 18 months, which included regular PSA sampling, 3T mpMRI, and ultrasound/MR fusion-guided biopsies systematic and targeted at the site of the focal treatment. RESULTS: The focal ablation procedure was carried out in an outpatient setting regimen with optimal clinical and biochemical outcomes. No recurrence was detected throughout the follow-up period. CONCLUSION: TPLA focal treatment effectively manages local recurrences of RT refractory prostate cancer without side-effects or complications. Preservation of quality of life and functional outcomes, along with a >70% reduction in PSA, were achieved. ADVANCES IN KNOWLEDGE: Our study investigated TPLA as a salvage treatment for low-risk recurrent prostate cancer after RT, demonstrating its tolerability, feasibility, and effectiveness. The British Institute of Radiology. 2023-10-18 /pmc/articles/PMC10630978/ /pubmed/37942495 http://dx.doi.org/10.1259/bjro.20230042 Text en © 2023 The Authors. Published by the British Institute of Radiology https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Original Research Manenti, Guglielmo Nezzo, Marco Ryan, Colleen Patricia Fraioli, Federico Romeo Carreri, Beatrice Gigliotti, Paola Elda Angeloni, Cecilia Di Pietro, Francesca De Angeli, Martina Perretta, Tommaso D'Angelillo, Rolando Maria Garaci, Francesco Giuseppe Transperineal laser ablation (TPLA) with ultrasound/MRI fusion guidance in the treatment of localized radiotherapy-resistant prostate cancer |
title | Transperineal laser ablation (TPLA) with ultrasound/MRI fusion guidance in the treatment of localized radiotherapy-resistant prostate cancer |
title_full | Transperineal laser ablation (TPLA) with ultrasound/MRI fusion guidance in the treatment of localized radiotherapy-resistant prostate cancer |
title_fullStr | Transperineal laser ablation (TPLA) with ultrasound/MRI fusion guidance in the treatment of localized radiotherapy-resistant prostate cancer |
title_full_unstemmed | Transperineal laser ablation (TPLA) with ultrasound/MRI fusion guidance in the treatment of localized radiotherapy-resistant prostate cancer |
title_short | Transperineal laser ablation (TPLA) with ultrasound/MRI fusion guidance in the treatment of localized radiotherapy-resistant prostate cancer |
title_sort | transperineal laser ablation (tpla) with ultrasound/mri fusion guidance in the treatment of localized radiotherapy-resistant prostate cancer |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630978/ https://www.ncbi.nlm.nih.gov/pubmed/37942495 http://dx.doi.org/10.1259/bjro.20230042 |
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