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APT weighted imaging in diffuse gliomas

Amide proton transfer-weighted (APTw) imaging is a non-invasive molecular MRI technique with a wide range of applications in neuroradiology and particularly neuro-oncology imaging. More than 15 years of pre-clinical experiments and clinical studies have demonstrated that APTw metrics are reproducibl...

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Autores principales: Nichelli, Lucia, Zaiss, Moritz, Casagranda, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The British Institute of Radiology. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630980/
https://www.ncbi.nlm.nih.gov/pubmed/37942492
http://dx.doi.org/10.1259/bjro.20230025
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author Nichelli, Lucia
Zaiss, Moritz
Casagranda, Stefano
author_facet Nichelli, Lucia
Zaiss, Moritz
Casagranda, Stefano
author_sort Nichelli, Lucia
collection PubMed
description Amide proton transfer-weighted (APTw) imaging is a non-invasive molecular MRI technique with a wide range of applications in neuroradiology and particularly neuro-oncology imaging. More than 15 years of pre-clinical experiments and clinical studies have demonstrated that APTw metrics are reproducible and reliable, leading to large-scale clinical acceptance. At present, major vendors of MRI scanners provide APTw sequences upon request. However, most neuroradiologists are unfamiliar with this advanced MRI contrast, its related metrics, and its established added value to patient care. In this manuscript, we present the APTw contrast and illustrate its clinical potential for glioma patients, before and after tumor therapy. We also show common artifacts of APTw imaging and discuss potential limitations and future refinements. Our goal is to suggest how this emerging technique can aid in diffuse gliomas work-up.
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spelling pubmed-106309802023-11-07 APT weighted imaging in diffuse gliomas Nichelli, Lucia Zaiss, Moritz Casagranda, Stefano BJR Open Pictorial Review Amide proton transfer-weighted (APTw) imaging is a non-invasive molecular MRI technique with a wide range of applications in neuroradiology and particularly neuro-oncology imaging. More than 15 years of pre-clinical experiments and clinical studies have demonstrated that APTw metrics are reproducible and reliable, leading to large-scale clinical acceptance. At present, major vendors of MRI scanners provide APTw sequences upon request. However, most neuroradiologists are unfamiliar with this advanced MRI contrast, its related metrics, and its established added value to patient care. In this manuscript, we present the APTw contrast and illustrate its clinical potential for glioma patients, before and after tumor therapy. We also show common artifacts of APTw imaging and discuss potential limitations and future refinements. Our goal is to suggest how this emerging technique can aid in diffuse gliomas work-up. The British Institute of Radiology. 2023-10-03 /pmc/articles/PMC10630980/ /pubmed/37942492 http://dx.doi.org/10.1259/bjro.20230025 Text en © 2023 The Authors. Published by the British Institute of Radiology https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pictorial Review
Nichelli, Lucia
Zaiss, Moritz
Casagranda, Stefano
APT weighted imaging in diffuse gliomas
title APT weighted imaging in diffuse gliomas
title_full APT weighted imaging in diffuse gliomas
title_fullStr APT weighted imaging in diffuse gliomas
title_full_unstemmed APT weighted imaging in diffuse gliomas
title_short APT weighted imaging in diffuse gliomas
title_sort apt weighted imaging in diffuse gliomas
topic Pictorial Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630980/
https://www.ncbi.nlm.nih.gov/pubmed/37942492
http://dx.doi.org/10.1259/bjro.20230025
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