Induced pluripotent stem cells derived from patients carrying mitochondrial mutations exhibit altered bioenergetics and aberrant differentiation potential

BACKGROUND: Human mitochondrial DNA mutations are associated with common to rare mitochondrial disorders, which are multisystemic with complex clinical pathologies. The pathologies of these diseases are poorly understood and have no FDA-approved treatments leading to symptom management. Leigh syndro...

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Detalles Bibliográficos
Autores principales: Meshrkey, Fibi, Scheulin, Kelly M., Littlejohn, Christopher M., Stabach, Joshua, Saikia, Bibhuti, Thorat, Vedant, Huang, Yimin, LaFramboise, Thomas, Lesnefsky, Edward J., Rao, Raj R., West, Franklin D., Iyer, Shilpa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10631039/
https://www.ncbi.nlm.nih.gov/pubmed/37936209
http://dx.doi.org/10.1186/s13287-023-03546-7

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