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Clinical characteristics and therapeutic response of differentiated thyroid carcinoma with obesity and diabetes

BACKGROUND: The effects of obesity and diabetes on the clinical outcomes of differentiated thyroid cancer (DTC) remain unclear. OBJECTIVES: To explore the association between obesity and diabetes with pathological features and therapeutic response of DTC. METHODS: Patients were categorized based on...

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Autores principales: Wang, Xuan, Yu, Yang, Ji, Yanhui, Ma, Ziyu, Tan, Jian, Jia, Qiang, Li, Ning, Zheng, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10631042/
https://www.ncbi.nlm.nih.gov/pubmed/37940857
http://dx.doi.org/10.1186/s12885-023-11591-x
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author Wang, Xuan
Yu, Yang
Ji, Yanhui
Ma, Ziyu
Tan, Jian
Jia, Qiang
Li, Ning
Zheng, Wei
author_facet Wang, Xuan
Yu, Yang
Ji, Yanhui
Ma, Ziyu
Tan, Jian
Jia, Qiang
Li, Ning
Zheng, Wei
author_sort Wang, Xuan
collection PubMed
description BACKGROUND: The effects of obesity and diabetes on the clinical outcomes of differentiated thyroid cancer (DTC) remain unclear. OBJECTIVES: To explore the association between obesity and diabetes with pathological features and therapeutic response of DTC. METHODS: Patients were categorized based on body mass index (BMI) and glycemic status. Compare the correlation between BMI and glycemic status with pathological features and therapeutic response of DTC. To analyze the independent risk factors for the aggressiveness of DTC. RESULTS: The proportion of patients with bilateral tumors was higher in the overweight, obese and diabetes group (P = 0.001, 0.045). The overweight group demonstrated a higher TNM stage (P = 0.004), while the T and TNM stages were higher in the diabetes group (P = 0.032, 0.000). The probability of distant metastasis increases by 37.4% for each unit of BMI increase (odds ratio (OR) = 1.374, CI 95% 1.061–1.778, P < 0.05). The BMI of Biochemical Incomplete Response (BIR) is significantly higher than that of Excellent Response (ER) (P = 0.015), the fasting plasma glucose (FPG) of Structural Incomplete (SIR) was significantly higher than that of ER and BIR (P = 0.030, 0.014). CONCLUSION: Obesity and diabetes have effect on DTC aggressiveness. BMI and FPG have correlation with the therapeutic response of DTC patients.
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spelling pubmed-106310422023-11-07 Clinical characteristics and therapeutic response of differentiated thyroid carcinoma with obesity and diabetes Wang, Xuan Yu, Yang Ji, Yanhui Ma, Ziyu Tan, Jian Jia, Qiang Li, Ning Zheng, Wei BMC Cancer Research BACKGROUND: The effects of obesity and diabetes on the clinical outcomes of differentiated thyroid cancer (DTC) remain unclear. OBJECTIVES: To explore the association between obesity and diabetes with pathological features and therapeutic response of DTC. METHODS: Patients were categorized based on body mass index (BMI) and glycemic status. Compare the correlation between BMI and glycemic status with pathological features and therapeutic response of DTC. To analyze the independent risk factors for the aggressiveness of DTC. RESULTS: The proportion of patients with bilateral tumors was higher in the overweight, obese and diabetes group (P = 0.001, 0.045). The overweight group demonstrated a higher TNM stage (P = 0.004), while the T and TNM stages were higher in the diabetes group (P = 0.032, 0.000). The probability of distant metastasis increases by 37.4% for each unit of BMI increase (odds ratio (OR) = 1.374, CI 95% 1.061–1.778, P < 0.05). The BMI of Biochemical Incomplete Response (BIR) is significantly higher than that of Excellent Response (ER) (P = 0.015), the fasting plasma glucose (FPG) of Structural Incomplete (SIR) was significantly higher than that of ER and BIR (P = 0.030, 0.014). CONCLUSION: Obesity and diabetes have effect on DTC aggressiveness. BMI and FPG have correlation with the therapeutic response of DTC patients. BioMed Central 2023-11-08 /pmc/articles/PMC10631042/ /pubmed/37940857 http://dx.doi.org/10.1186/s12885-023-11591-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Wang, Xuan
Yu, Yang
Ji, Yanhui
Ma, Ziyu
Tan, Jian
Jia, Qiang
Li, Ning
Zheng, Wei
Clinical characteristics and therapeutic response of differentiated thyroid carcinoma with obesity and diabetes
title Clinical characteristics and therapeutic response of differentiated thyroid carcinoma with obesity and diabetes
title_full Clinical characteristics and therapeutic response of differentiated thyroid carcinoma with obesity and diabetes
title_fullStr Clinical characteristics and therapeutic response of differentiated thyroid carcinoma with obesity and diabetes
title_full_unstemmed Clinical characteristics and therapeutic response of differentiated thyroid carcinoma with obesity and diabetes
title_short Clinical characteristics and therapeutic response of differentiated thyroid carcinoma with obesity and diabetes
title_sort clinical characteristics and therapeutic response of differentiated thyroid carcinoma with obesity and diabetes
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10631042/
https://www.ncbi.nlm.nih.gov/pubmed/37940857
http://dx.doi.org/10.1186/s12885-023-11591-x
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