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Biocatalytic reductive amination as a route to isotopically labelled amino acids suitable for analysis of large proteins by NMR

We demonstrate an atom-efficient and easy to use H(2)-driven biocatalytic platform for the enantioselective incorporation of (2)H-atoms into amino acids. By combining the biocatalytic deuteration catalyst with amino acid dehydrogenase enzymes capable of reductive amination, we synthesised a library...

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Detalles Bibliográficos
Autores principales:	Rowbotham, Jack S., Nicholson, Jake H., Ramirez, Miguel A., Urata, Kouji, Todd, Peter M. T., Karunanithy, Gogulan, Lauterbach, Lars, Reeve, Holly A., Baldwin, Andrew J., Vincent, Kylie A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2023
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10631221/ https://www.ncbi.nlm.nih.gov/pubmed/37969586 http://dx.doi.org/10.1039/d3sc01718d

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