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Cancer Relevance of Circulating Antibodies Against LINE-1 Antigens in Humans

Long interspersed nuclear element-1 (LINE-1 or L1), the most abundant family of autonomous retrotransposons occupying over 17% of human DNA, is epigenetically silenced in normal tissues by the mechanisms involving p53 but is frequently derepressed in cancer, suggesting that L1-encoded proteins may a...

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Detalles Bibliográficos
Autores principales:	Vylegzhanina, Alexandra V., Bespalov, Ivan A., Novototskaya-Vlasova, Ksenia A., Hall, Brandon M., Gleiberman, Anatoli S., Yu, Han, Leontieva, Olga V., Leonova, Katerina I., Kurnasov, Oleg V., Osterman, Andrei L., Dy, Grace K., Komissarov, Alexey A., Vasilieva, Elena, Gehlhausen, Jeff, Iwasaki, Akiko, Ambrosone, Christine B., Tsuji, Takemasa, Matsuzaki, Junko, Odunsi, Kunle, Andrianova, Ekaterina L., Gudkov, Andrei V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10631453/ https://www.ncbi.nlm.nih.gov/pubmed/37870410 http://dx.doi.org/10.1158/2767-9764.CRC-23-0289

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