DHA Shortage Causes the Early Degeneration of Photoreceptors and RPE in Mice With Peroxisomal β-Oxidation Deficiency

PURPOSE: Patients deficient in peroxisomal β-oxidation, which is essential for the synthesis of docosahexaenoic acid (DHA, C22:6n-3) and breakdown of very-long-chain polyunsaturated fatty acids (VLC-PUFAs), both important components of photoreceptor outer segments, develop retinopathy present with r...

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Detalles Bibliográficos
Autores principales: Swinkels, Daniëlle, Kocherlakota, Sai, Das, Yannick, Dane, Adriaan D., Wever, Eric J. M., Vaz, Frédéric M., Bazan, Nicolas G., Van Veldhoven, Paul P., Baes, Myriam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2023
Materias:
Retinal Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10631513/
https://www.ncbi.nlm.nih.gov/pubmed/37934161
http://dx.doi.org/10.1167/iovs.64.14.10

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