DCAF14 regulates CDT2 to promote SET8-dependent replication fork protection

DDB1- and CUL4-associated factors (DCAFs) CDT2 and DCAF14 are substrate receptors for Cullin4–RING E3 ubiquitin ligase (CRL4) complexes. CDT2 is responsible for PCNA-coupled proteolysis of substrates CDT1, p21, and SET8 during S-phase of cell cycle. DCAF14 functions at stalled replication forks to p...

Descripción completa

Detalles Bibliográficos
Autores principales: Tirado-Class, Neysha, Hathaway, Caitlin, Nelligan, Anthony, Nguyen, Thuan, Dungrawala, Huzefa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10631547/
https://www.ncbi.nlm.nih.gov/pubmed/37940188
http://dx.doi.org/10.26508/lsa.202302230

Ejemplares similares

Ejemplares similares