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Heterogeneity of HIV-1 latent reservoirs

Antiretroviral therapy (ART) can effectively inhibit human immunodeficiency virus-1 (HIV-1) replication, but is not curative due to the existence of a stable viral latent reservoir harboring replication-competent proviruses. In order to reduce or eliminate the HIV-1 latent reservoir, characteristics...

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Detalles Bibliográficos
Autores principales: Zhao, Jia-Cong, Deng, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10631589/
https://www.ncbi.nlm.nih.gov/pubmed/33273337
http://dx.doi.org/10.1097/CM9.0000000000001085
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author Zhao, Jia-Cong
Deng, Kai
author_facet Zhao, Jia-Cong
Deng, Kai
author_sort Zhao, Jia-Cong
collection PubMed
description Antiretroviral therapy (ART) can effectively inhibit human immunodeficiency virus-1 (HIV-1) replication, but is not curative due to the existence of a stable viral latent reservoir harboring replication-competent proviruses. In order to reduce or eliminate the HIV-1 latent reservoir, characteristics of the latently infected cells need to be intensively studied, and a comprehensive understanding of the heterogenous nature of the latent reservoir will be critical to develop novel therapeutic strategies. Here, we discuss the different cell types and mechanisms contributing to the complexity and heterogeneity of HIV-1 latent reservoirs, and summarize the key challenges to the development of cure strategies for acquired immunodeficiency syndrome (AIDS).
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spelling pubmed-106315892020-12-05 Heterogeneity of HIV-1 latent reservoirs Zhao, Jia-Cong Deng, Kai Chin Med J (Engl) Review Articles Antiretroviral therapy (ART) can effectively inhibit human immunodeficiency virus-1 (HIV-1) replication, but is not curative due to the existence of a stable viral latent reservoir harboring replication-competent proviruses. In order to reduce or eliminate the HIV-1 latent reservoir, characteristics of the latently infected cells need to be intensively studied, and a comprehensive understanding of the heterogenous nature of the latent reservoir will be critical to develop novel therapeutic strategies. Here, we discuss the different cell types and mechanisms contributing to the complexity and heterogeneity of HIV-1 latent reservoirs, and summarize the key challenges to the development of cure strategies for acquired immunodeficiency syndrome (AIDS). Lippincott Williams & Wilkins 2020-12-05 2020-09-15 /pmc/articles/PMC10631589/ /pubmed/33273337 http://dx.doi.org/10.1097/CM9.0000000000001085 Text en Copyright © 2020 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Review Articles
Zhao, Jia-Cong
Deng, Kai
Heterogeneity of HIV-1 latent reservoirs
title Heterogeneity of HIV-1 latent reservoirs
title_full Heterogeneity of HIV-1 latent reservoirs
title_fullStr Heterogeneity of HIV-1 latent reservoirs
title_full_unstemmed Heterogeneity of HIV-1 latent reservoirs
title_short Heterogeneity of HIV-1 latent reservoirs
title_sort heterogeneity of hiv-1 latent reservoirs
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10631589/
https://www.ncbi.nlm.nih.gov/pubmed/33273337
http://dx.doi.org/10.1097/CM9.0000000000001085
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