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Corneal epithelialinduced by combined small incision lenticule extraction and accelerated corneal collagen crosslinking for myopia
PURPOSE: To evaluate the changes of the corneal epithelial thickness (ET) profile induced by combined small incision lenticule extraction and accelerated corneal collagen crosslinking (SMILE-xtra) for myopia compared with the standard small incision lenticule extraction (SMILE). SETTING: Nuri Eye Ho...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10631666/ https://www.ncbi.nlm.nih.gov/pubmed/37939068 http://dx.doi.org/10.1371/journal.pone.0294121 |
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author | Kim, Kook Young Bae, Sinwoo Lee, Seongjun Lee, Yongwoo |
author_facet | Kim, Kook Young Bae, Sinwoo Lee, Seongjun Lee, Yongwoo |
author_sort | Kim, Kook Young |
collection | PubMed |
description | PURPOSE: To evaluate the changes of the corneal epithelial thickness (ET) profile induced by combined small incision lenticule extraction and accelerated corneal collagen crosslinking (SMILE-xtra) for myopia compared with the standard small incision lenticule extraction (SMILE). SETTING: Nuri Eye Hospital, 61, Dunsan-ro, Seo-gu, Daejeon, 35233, Korea. DESIGN: Retrospective cross-sectional study. METHODS: Thirty-one myopic eye undergoing SMILE-xtra and control group of 36 myopic eyes undergoing SMILE were retrospectively analyzed. Spectral-domain optical coherence tomography (CIRRUS™ HD-OCT 5000, ZEISS, Dublin, CA) was used to measure corneal ET of 17 zones within the central 7-mm zone at preoperative, postoperative 1 month, 3 months and 6 months. Postoperative ET alterations were analyzed for correlation with treatment parameters. RESULTS: There was no difference in preoperative mean age, postoperative MRSE, visual acuity, and ablation depth between the two groups, and there was a significant difference in preoperative central corneal thickness. Both groups showed the greatest increase in corneal ET in the paracentral area on the inferotemporal area, respectively, for 6 months. The preoperative MRSE and the ablation depth showed significant correlation with the postoperative epithelial thickening in mid-peripheral sectors in both groups, and significant negative correlations in paracentral sectors only in SMILE-xtra group. CONCLUSIONS: It is significant as the first study to compare corneal epithelial remodeling between SMILE and SMILE with accelerated corneal collagen crosslinking. The SMILE-xtra with the relatively large corneal ablation did not show a significant difference in the pattern of corneal epithelial remodeling compared to the SMILE group. |
format | Online Article Text |
id | pubmed-10631666 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-106316662023-11-08 Corneal epithelialinduced by combined small incision lenticule extraction and accelerated corneal collagen crosslinking for myopia Kim, Kook Young Bae, Sinwoo Lee, Seongjun Lee, Yongwoo PLoS One Research Article PURPOSE: To evaluate the changes of the corneal epithelial thickness (ET) profile induced by combined small incision lenticule extraction and accelerated corneal collagen crosslinking (SMILE-xtra) for myopia compared with the standard small incision lenticule extraction (SMILE). SETTING: Nuri Eye Hospital, 61, Dunsan-ro, Seo-gu, Daejeon, 35233, Korea. DESIGN: Retrospective cross-sectional study. METHODS: Thirty-one myopic eye undergoing SMILE-xtra and control group of 36 myopic eyes undergoing SMILE were retrospectively analyzed. Spectral-domain optical coherence tomography (CIRRUS™ HD-OCT 5000, ZEISS, Dublin, CA) was used to measure corneal ET of 17 zones within the central 7-mm zone at preoperative, postoperative 1 month, 3 months and 6 months. Postoperative ET alterations were analyzed for correlation with treatment parameters. RESULTS: There was no difference in preoperative mean age, postoperative MRSE, visual acuity, and ablation depth between the two groups, and there was a significant difference in preoperative central corneal thickness. Both groups showed the greatest increase in corneal ET in the paracentral area on the inferotemporal area, respectively, for 6 months. The preoperative MRSE and the ablation depth showed significant correlation with the postoperative epithelial thickening in mid-peripheral sectors in both groups, and significant negative correlations in paracentral sectors only in SMILE-xtra group. CONCLUSIONS: It is significant as the first study to compare corneal epithelial remodeling between SMILE and SMILE with accelerated corneal collagen crosslinking. The SMILE-xtra with the relatively large corneal ablation did not show a significant difference in the pattern of corneal epithelial remodeling compared to the SMILE group. Public Library of Science 2023-11-08 /pmc/articles/PMC10631666/ /pubmed/37939068 http://dx.doi.org/10.1371/journal.pone.0294121 Text en © 2023 Kim et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Kim, Kook Young Bae, Sinwoo Lee, Seongjun Lee, Yongwoo Corneal epithelialinduced by combined small incision lenticule extraction and accelerated corneal collagen crosslinking for myopia |
title | Corneal epithelialinduced by combined small incision lenticule extraction and accelerated corneal collagen crosslinking for myopia |
title_full | Corneal epithelialinduced by combined small incision lenticule extraction and accelerated corneal collagen crosslinking for myopia |
title_fullStr | Corneal epithelialinduced by combined small incision lenticule extraction and accelerated corneal collagen crosslinking for myopia |
title_full_unstemmed | Corneal epithelialinduced by combined small incision lenticule extraction and accelerated corneal collagen crosslinking for myopia |
title_short | Corneal epithelialinduced by combined small incision lenticule extraction and accelerated corneal collagen crosslinking for myopia |
title_sort | corneal epithelialinduced by combined small incision lenticule extraction and accelerated corneal collagen crosslinking for myopia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10631666/ https://www.ncbi.nlm.nih.gov/pubmed/37939068 http://dx.doi.org/10.1371/journal.pone.0294121 |
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