Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness

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Drug-resistant Plasmodium falciparum parasites have swept across Southeast Asia and now threaten Africa. By implementing a P. falciparum genetic cross using humanized mice, we report the identification of key determinants of resistance to artemisinin (ART) and piperaquine (PPQ) in the dominant Asian...

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Detalles Bibliográficos
Autores principales: Mok, Sachel, Yeo, Tomas, Hong, Davin, Shears, Melanie J., Ross, Leila S., Ward, Kurt E., Dhingra, Satish K., Kanai, Mariko, Bridgford, Jessica L., Tripathi, Abhai K., Mlambo, Godfree, Burkhard, Anna Y., Ansbro, Megan R., Fairhurst, Kate J., Gil-Iturbe, Eva, Park, Heekuk, Rozenberg, Felix D., Kim, Jonathan, Mancia, Filippo, Fairhurst, Rick M., Quick, Matthias, Uhlemann, Anne-Catrin, Sinnis, Photini, Fidock, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10631731/
https://www.ncbi.nlm.nih.gov/pubmed/37939186
http://dx.doi.org/10.1126/sciadv.adi2364
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