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Evaluation of Free Valproate Concentration in Critically Ill Patients

Protein binding of valproate is variable in ICU patients, and the total valproate concentration does not predict the free valproate concentration, even when correcting for albumin. We sought to quantify valproate free concentration among ICU patients, identify risk factors associated with an increas...

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Detalles Bibliográficos
Autores principales:	Brown, Caitlin S., Liu, JiTong, Riker, Richard R., Mara, Kristin C., Rabinstein, Alejandro A., Fraser, Gilles L., May, Teresa L., Seder, David, Gagnon, David J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2022
Materias:	Original Clinical Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10631734/ https://www.ncbi.nlm.nih.gov/pubmed/37942235 http://dx.doi.org/10.1097/CCE.0000000000000746

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