Novel insights into the ecDNA formation mechanism involving MSH3 in methotrexate-resistant human colorectal cancer cells

Extrachromosomal DNAs (ecDNAs), also known as double minutes (DMs), can induce a fast increase in gene copy numbers and promote the development of cancer, including drug resistance. MutS homolog 3 (MSH3), a key protein in mismatch repair, has been indicated to participate in the regulation of DNA do...

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Detalles Bibliográficos
Autores principales: Wang, Xu, Qu, Yanan, Xing, Ruonan, Zhou, Jing, Liu, Yanghe, Zhang, Huishu, Zhu, Jing, Ma, Jinfa, Cui, Xiaobo, Song, Tiantian, Xing, Shukai, Ji, Guohua, Liu, Peng, Sun, Wenjing, Fu, Songbin, Meng, Xiangning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10631765/
https://www.ncbi.nlm.nih.gov/pubmed/37888748
http://dx.doi.org/10.3892/ijo.2023.5582

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