Population pharmacokinetics of a combination of miltefosine and paromomycin in Eastern African children and adults with visceral leishmaniasis

OBJECTIVES: To improve visceral leishmaniasis (VL) treatment in Eastern Africa, 14- and 28-day combination regimens of paromomycin plus allometrically dosed miltefosine were evaluated. As the majority of patients affected by VL are children, adequate paediatric exposure to miltefosine and paromomyci...

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Detalles Bibliográficos
Autores principales: Verrest, Luka, Roseboom, Ignace C, Wasunna, Monique, Mbui, Jane, Njenga, Simon, Musa, Ahmed M, Olobo, Joseph, Mohammed, Rezika, Ritmeijer, Koert, Chu, Wan-Yu, Huitema, Alwin D R, Solomos, Alexandra, Alves, Fabiana, Dorlo, Thomas P C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10631828/
https://www.ncbi.nlm.nih.gov/pubmed/37726401
http://dx.doi.org/10.1093/jac/dkad286

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10631828/
https://www.ncbi.nlm.nih.gov/pubmed/37726401
http://dx.doi.org/10.1093/jac/dkad286

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