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Recent trends and perspectives in reconstruction and regeneration of intra/extra-oral wounds using tissue-engineered oral mucosa equivalents

Many conditions, including cancer, trauma, and congenital anomalies, can damage the oral mucosa. Multiple cultures of oral mucosal cells have been used for biocompatibility tests and oral biology studies. In recent decades, the clinical translation of tissue-engineered products has progressed signif...

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Detalles Bibliográficos
Autores principales: Izumi, Kenji, Yortchan, Witsanu, Aizawa, Yuka, Kobayashi, Ryota, Hoshikawa, Emi, Ling, Yiwei, Suzuki, Ayako
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632115/
https://www.ncbi.nlm.nih.gov/pubmed/37954029
http://dx.doi.org/10.1016/j.jdsr.2023.10.002
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author Izumi, Kenji
Yortchan, Witsanu
Aizawa, Yuka
Kobayashi, Ryota
Hoshikawa, Emi
Ling, Yiwei
Suzuki, Ayako
author_facet Izumi, Kenji
Yortchan, Witsanu
Aizawa, Yuka
Kobayashi, Ryota
Hoshikawa, Emi
Ling, Yiwei
Suzuki, Ayako
author_sort Izumi, Kenji
collection PubMed
description Many conditions, including cancer, trauma, and congenital anomalies, can damage the oral mucosa. Multiple cultures of oral mucosal cells have been used for biocompatibility tests and oral biology studies. In recent decades, the clinical translation of tissue-engineered products has progressed significantly in developing tangible therapies and inspiring advancements in medical science. However, the reconstruction of an intraoral mucosa defect remains a significant challenge. Despite the drawbacks of donor-site morbidity and limited tissue supply, the use of autologous oral mucosa remains the gold standard for oral mucosa reconstruction and repair. Tissue engineering offers a promising solution for repairing and reconstructing oral mucosa tissues. Cell- and scaffold-based tissue engineering approaches have been employed to treat various soft tissue defects, suggesting the potential clinical use of tissue-engineered oral mucosa (TEOMs). In this review, we first cover the recent trends in the reconstruction and regeneration of extra-/intra-oral wounds using TEOMs. Next, we describe the current status and challenges of TEOMs. Finally, future strategic approaches and potential technologies to support the advancement of TEOMs for clinical use are discussed.
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spelling pubmed-106321152023-11-10 Recent trends and perspectives in reconstruction and regeneration of intra/extra-oral wounds using tissue-engineered oral mucosa equivalents Izumi, Kenji Yortchan, Witsanu Aizawa, Yuka Kobayashi, Ryota Hoshikawa, Emi Ling, Yiwei Suzuki, Ayako Jpn Dent Sci Rev Article Many conditions, including cancer, trauma, and congenital anomalies, can damage the oral mucosa. Multiple cultures of oral mucosal cells have been used for biocompatibility tests and oral biology studies. In recent decades, the clinical translation of tissue-engineered products has progressed significantly in developing tangible therapies and inspiring advancements in medical science. However, the reconstruction of an intraoral mucosa defect remains a significant challenge. Despite the drawbacks of donor-site morbidity and limited tissue supply, the use of autologous oral mucosa remains the gold standard for oral mucosa reconstruction and repair. Tissue engineering offers a promising solution for repairing and reconstructing oral mucosa tissues. Cell- and scaffold-based tissue engineering approaches have been employed to treat various soft tissue defects, suggesting the potential clinical use of tissue-engineered oral mucosa (TEOMs). In this review, we first cover the recent trends in the reconstruction and regeneration of extra-/intra-oral wounds using TEOMs. Next, we describe the current status and challenges of TEOMs. Finally, future strategic approaches and potential technologies to support the advancement of TEOMs for clinical use are discussed. Elsevier 2023-12 2023-10-25 /pmc/articles/PMC10632115/ /pubmed/37954029 http://dx.doi.org/10.1016/j.jdsr.2023.10.002 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Izumi, Kenji
Yortchan, Witsanu
Aizawa, Yuka
Kobayashi, Ryota
Hoshikawa, Emi
Ling, Yiwei
Suzuki, Ayako
Recent trends and perspectives in reconstruction and regeneration of intra/extra-oral wounds using tissue-engineered oral mucosa equivalents
title Recent trends and perspectives in reconstruction and regeneration of intra/extra-oral wounds using tissue-engineered oral mucosa equivalents
title_full Recent trends and perspectives in reconstruction and regeneration of intra/extra-oral wounds using tissue-engineered oral mucosa equivalents
title_fullStr Recent trends and perspectives in reconstruction and regeneration of intra/extra-oral wounds using tissue-engineered oral mucosa equivalents
title_full_unstemmed Recent trends and perspectives in reconstruction and regeneration of intra/extra-oral wounds using tissue-engineered oral mucosa equivalents
title_short Recent trends and perspectives in reconstruction and regeneration of intra/extra-oral wounds using tissue-engineered oral mucosa equivalents
title_sort recent trends and perspectives in reconstruction and regeneration of intra/extra-oral wounds using tissue-engineered oral mucosa equivalents
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632115/
https://www.ncbi.nlm.nih.gov/pubmed/37954029
http://dx.doi.org/10.1016/j.jdsr.2023.10.002
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