Mouse genome rewriting and tailoring of three important disease loci

Genetically engineered mouse models (GEMMs) help us to understand human pathologies and develop new therapies, yet faithfully recapitulating human diseases in mice is challenging. Advances in genomics have highlighted the importance of non-coding regulatory genome sequences, which control spatiotemp...

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Detalles Bibliográficos
Autores principales: Zhang, Weimin, Golynker, Ilona, Brosh, Ran, Fajardo, Alvaro, Zhu, Yinan, Wudzinska, Aleksandra M., Ordoñez, Raquel, Ribeiro-dos-Santos, André M., Carrau, Lucia, Damani-Yokota, Payal, Yeung, Stephen T., Khairallah, Camille, Vela Gartner, Antonio, Chalhoub, Noor, Huang, Emily, Ashe, Hannah J., Khanna, Kamal M., Maurano, Matthew T., Kim, Sang Yong, tenOever, Benjamin R., Boeke, Jef D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632133/
https://www.ncbi.nlm.nih.gov/pubmed/37914927
http://dx.doi.org/10.1038/s41586-023-06675-4

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