Effects of psoriasis and psoralen exposure on the somatic mutation landscape of the skin

Somatic mutations are hypothesized to play a role in many non-neoplastic diseases. We performed whole-exome sequencing of 1,182 microbiopsies dissected from lesional and nonlesional epidermis from 111 patients with psoriasis to search for evidence that somatic mutations in keratinocytes may influenc...

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Detalles Bibliográficos
Autores principales: Olafsson, Sigurgeir, Rodriguez, Elke, Lawson, Andrew R. J., Abascal, Federico, Huber, Axel Rosendahl, Suembuel, Melike, Jones, Philip H., Gerdes, Sascha, Martincorena, Iñigo, Weidinger, Stephan, Campbell, Peter J., Anderson, Carl A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632143/
https://www.ncbi.nlm.nih.gov/pubmed/37884686
http://dx.doi.org/10.1038/s41588-023-01545-1

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