Accumulation of 8-oxodG within the human mitochondrial genome positively associates with transcription

Mitochondrial DNA (mtDNA) can be subject to internal and environmental stressors that lead to oxidatively generated damage and the formation of 8-oxo-7,8-dihydro-2′-deoxyguanine (8-oxodG). The accumulation of 8-oxodG has been linked to degenerative diseases and aging, as well as cancer. Despite the...

Descripción completa

Detalles Bibliográficos
Autores principales: Scala, Giovanni, Ambrosio, Susanna, Menna, Margherita, Gorini, Francesca, Caiazza, Carmen, Cooke, Marcus S, Majello, Barbara, Amente, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Application Notes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632194/
https://www.ncbi.nlm.nih.gov/pubmed/37954575
http://dx.doi.org/10.1093/nargab/lqad100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632194/
https://www.ncbi.nlm.nih.gov/pubmed/37954575
http://dx.doi.org/10.1093/nargab/lqad100

Ejemplares similares