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Low prolactin level identifies hypoactive sexual desire disorder women with a reduced inhibition profile

PURPOSE: Data on the role of prolactin (PRL) in the physiologic range in the female sexual response are scanty. We aimed at investigating the association between PRL and sexual function as assessed by the Female Sexual Function Index (FSFI). We explored the presence of a cut-off level of PRL able to...

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Autores principales: Maseroli, E., Verde, N., Cipriani, S., Rastrelli, G., Alfaroli, C., Ravelli, S. A., Costeniero, D., Scairati, R., Minnetti, M., Petraglia, F., Auriemma, R. S., Nappi, R. E., Maggi, M., Vignozzi, L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632269/
https://www.ncbi.nlm.nih.gov/pubmed/37204690
http://dx.doi.org/10.1007/s40618-023-02101-8
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author Maseroli, E.
Verde, N.
Cipriani, S.
Rastrelli, G.
Alfaroli, C.
Ravelli, S. A.
Costeniero, D.
Scairati, R.
Minnetti, M.
Petraglia, F.
Auriemma, R. S.
Nappi, R. E.
Maggi, M.
Vignozzi, L.
author_facet Maseroli, E.
Verde, N.
Cipriani, S.
Rastrelli, G.
Alfaroli, C.
Ravelli, S. A.
Costeniero, D.
Scairati, R.
Minnetti, M.
Petraglia, F.
Auriemma, R. S.
Nappi, R. E.
Maggi, M.
Vignozzi, L.
author_sort Maseroli, E.
collection PubMed
description PURPOSE: Data on the role of prolactin (PRL) in the physiologic range in the female sexual response are scanty. We aimed at investigating the association between PRL and sexual function as assessed by the Female Sexual Function Index (FSFI). We explored the presence of a cut-off level of PRL able to identify Hypoactive Sexual Desire Disorder (HSDD). METHODS: 277 pre- and post-menopausal women consulting for Female Sexual Dysfunction (FSD) and sexually active were enrolled in an observational, retrospective study. 42 women were used as no-FSD controls. A clinical, biochemical and psychosexual evaluation was performed. The main outcome measures were: FSFI, Female Sexual Distress Scale-Revised, Middlesex Hospital Questionnaire and Sexual excitation/sexual inhibition scale (SIS/SES). RESULTS: Normo-PRL FSD women (n = 264) showed lower FSFI Desire score than controls (n = 42), and higher than hyper-PRL FSD women (n = 13). These differences emerged both in pre-menopausal and post-menopausal subjects. In the normo-PRL FSD group, those with PRL in the higher quintile reported higher FSFI Desire scores than those with PRL in the lowest quintile. Women with HSDD presented a lower PRL level than those without (p = 0.032). A ROC curve analysis for PRL showed an accuracy of 0.610 ± 0.044 (p = 0.014) in predicting HSDD. With a threshold of < 9.83 μg/L, sensitivity and specificity for HSDD were 63% and 56%, respectively. Subjects with PRL < 9.83 μg/L also reported lower sexual inhibition (p = 0.006) and lower cortisol levels (p = 0.003) than those with PRL >  = 9.83 μg/L. CONCLUSIONS: Hyper-PRL is associated with low desire; however, among normo-PRL FSD women, those with the lowest levels demonstrated a poorer desire than those with the highest levels. PRL < 9.83 μg/L predicted HSDD and a lower sexual inhibitory trait. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40618-023-02101-8.
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spelling pubmed-106322692023-11-14 Low prolactin level identifies hypoactive sexual desire disorder women with a reduced inhibition profile Maseroli, E. Verde, N. Cipriani, S. Rastrelli, G. Alfaroli, C. Ravelli, S. A. Costeniero, D. Scairati, R. Minnetti, M. Petraglia, F. Auriemma, R. S. Nappi, R. E. Maggi, M. Vignozzi, L. J Endocrinol Invest Original Article PURPOSE: Data on the role of prolactin (PRL) in the physiologic range in the female sexual response are scanty. We aimed at investigating the association between PRL and sexual function as assessed by the Female Sexual Function Index (FSFI). We explored the presence of a cut-off level of PRL able to identify Hypoactive Sexual Desire Disorder (HSDD). METHODS: 277 pre- and post-menopausal women consulting for Female Sexual Dysfunction (FSD) and sexually active were enrolled in an observational, retrospective study. 42 women were used as no-FSD controls. A clinical, biochemical and psychosexual evaluation was performed. The main outcome measures were: FSFI, Female Sexual Distress Scale-Revised, Middlesex Hospital Questionnaire and Sexual excitation/sexual inhibition scale (SIS/SES). RESULTS: Normo-PRL FSD women (n = 264) showed lower FSFI Desire score than controls (n = 42), and higher than hyper-PRL FSD women (n = 13). These differences emerged both in pre-menopausal and post-menopausal subjects. In the normo-PRL FSD group, those with PRL in the higher quintile reported higher FSFI Desire scores than those with PRL in the lowest quintile. Women with HSDD presented a lower PRL level than those without (p = 0.032). A ROC curve analysis for PRL showed an accuracy of 0.610 ± 0.044 (p = 0.014) in predicting HSDD. With a threshold of < 9.83 μg/L, sensitivity and specificity for HSDD were 63% and 56%, respectively. Subjects with PRL < 9.83 μg/L also reported lower sexual inhibition (p = 0.006) and lower cortisol levels (p = 0.003) than those with PRL >  = 9.83 μg/L. CONCLUSIONS: Hyper-PRL is associated with low desire; however, among normo-PRL FSD women, those with the lowest levels demonstrated a poorer desire than those with the highest levels. PRL < 9.83 μg/L predicted HSDD and a lower sexual inhibitory trait. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40618-023-02101-8. Springer International Publishing 2023-05-18 2023 /pmc/articles/PMC10632269/ /pubmed/37204690 http://dx.doi.org/10.1007/s40618-023-02101-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Maseroli, E.
Verde, N.
Cipriani, S.
Rastrelli, G.
Alfaroli, C.
Ravelli, S. A.
Costeniero, D.
Scairati, R.
Minnetti, M.
Petraglia, F.
Auriemma, R. S.
Nappi, R. E.
Maggi, M.
Vignozzi, L.
Low prolactin level identifies hypoactive sexual desire disorder women with a reduced inhibition profile
title Low prolactin level identifies hypoactive sexual desire disorder women with a reduced inhibition profile
title_full Low prolactin level identifies hypoactive sexual desire disorder women with a reduced inhibition profile
title_fullStr Low prolactin level identifies hypoactive sexual desire disorder women with a reduced inhibition profile
title_full_unstemmed Low prolactin level identifies hypoactive sexual desire disorder women with a reduced inhibition profile
title_short Low prolactin level identifies hypoactive sexual desire disorder women with a reduced inhibition profile
title_sort low prolactin level identifies hypoactive sexual desire disorder women with a reduced inhibition profile
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632269/
https://www.ncbi.nlm.nih.gov/pubmed/37204690
http://dx.doi.org/10.1007/s40618-023-02101-8
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