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Ginsenoside compound-K attenuates OVX-induced osteoporosis via the suppression of RANKL-induced osteoclastogenesis and oxidative stress

Osteoporosis (OP), a systemic and chronic bone disease, is distinguished by low bone mass and destruction of bone microarchitecture. Ginsenoside Compound-K (CK), one of the metabolites of ginsenoside Rb1, has anti-aging, anti-inflammatory, anti-cancer, and hypolipidemic activities. We have demonstra...

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Autores principales: Ding, Lingli, Gao, Zhao, Wu, Siluo, Chen, Chen, Liu, Yamei, Wang, Min, Zhang, Yage, Li, Ling, Zou, Hong, Zhao, Guoping, Qin, Shengnan, Xu, Liangliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632357/
https://www.ncbi.nlm.nih.gov/pubmed/37940733
http://dx.doi.org/10.1007/s13659-023-00405-z
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author Ding, Lingli
Gao, Zhao
Wu, Siluo
Chen, Chen
Liu, Yamei
Wang, Min
Zhang, Yage
Li, Ling
Zou, Hong
Zhao, Guoping
Qin, Shengnan
Xu, Liangliang
author_facet Ding, Lingli
Gao, Zhao
Wu, Siluo
Chen, Chen
Liu, Yamei
Wang, Min
Zhang, Yage
Li, Ling
Zou, Hong
Zhao, Guoping
Qin, Shengnan
Xu, Liangliang
author_sort Ding, Lingli
collection PubMed
description Osteoporosis (OP), a systemic and chronic bone disease, is distinguished by low bone mass and destruction of bone microarchitecture. Ginsenoside Compound-K (CK), one of the metabolites of ginsenoside Rb1, has anti-aging, anti-inflammatory, anti-cancer, and hypolipidemic activities. We have demonstrated CK could promote osteogenesis and fracture healing in our previous study. However, the contribution of CK to osteoporosis has not been examined. In the present study, we investigated the effect of CK on osteoclastogenesis and ovariectomy (OVX)-induced osteoporosis. The results showed that CK inhibited receptor activator for nuclear factor-κB ligand (RANKL)-mediated osteoclast differentiation and reactive oxygen species (ROS) activity by inhibiting the phosphorylation of NF-κB p65 and oxidative stress in RAW264.7 cells. In addition, we also demonstrated that CK could inhibit bone resorption using bone marrow-derived macrophages. Furthermore, we demonstrated that CK attenuated bone loss by suppressing the activity of osteoclast and alleviating oxidative stress in vivo. Taken together, these results showed CK could inhibit osteoclastogenesis and prevent OVX-induced bone loss by inhibiting NF-κB signaling pathway. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13659-023-00405-z.
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spelling pubmed-106323572023-11-10 Ginsenoside compound-K attenuates OVX-induced osteoporosis via the suppression of RANKL-induced osteoclastogenesis and oxidative stress Ding, Lingli Gao, Zhao Wu, Siluo Chen, Chen Liu, Yamei Wang, Min Zhang, Yage Li, Ling Zou, Hong Zhao, Guoping Qin, Shengnan Xu, Liangliang Nat Prod Bioprospect Original Article Osteoporosis (OP), a systemic and chronic bone disease, is distinguished by low bone mass and destruction of bone microarchitecture. Ginsenoside Compound-K (CK), one of the metabolites of ginsenoside Rb1, has anti-aging, anti-inflammatory, anti-cancer, and hypolipidemic activities. We have demonstrated CK could promote osteogenesis and fracture healing in our previous study. However, the contribution of CK to osteoporosis has not been examined. In the present study, we investigated the effect of CK on osteoclastogenesis and ovariectomy (OVX)-induced osteoporosis. The results showed that CK inhibited receptor activator for nuclear factor-κB ligand (RANKL)-mediated osteoclast differentiation and reactive oxygen species (ROS) activity by inhibiting the phosphorylation of NF-κB p65 and oxidative stress in RAW264.7 cells. In addition, we also demonstrated that CK could inhibit bone resorption using bone marrow-derived macrophages. Furthermore, we demonstrated that CK attenuated bone loss by suppressing the activity of osteoclast and alleviating oxidative stress in vivo. Taken together, these results showed CK could inhibit osteoclastogenesis and prevent OVX-induced bone loss by inhibiting NF-κB signaling pathway. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13659-023-00405-z. Springer Nature Singapore 2023-11-09 /pmc/articles/PMC10632357/ /pubmed/37940733 http://dx.doi.org/10.1007/s13659-023-00405-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Ding, Lingli
Gao, Zhao
Wu, Siluo
Chen, Chen
Liu, Yamei
Wang, Min
Zhang, Yage
Li, Ling
Zou, Hong
Zhao, Guoping
Qin, Shengnan
Xu, Liangliang
Ginsenoside compound-K attenuates OVX-induced osteoporosis via the suppression of RANKL-induced osteoclastogenesis and oxidative stress
title Ginsenoside compound-K attenuates OVX-induced osteoporosis via the suppression of RANKL-induced osteoclastogenesis and oxidative stress
title_full Ginsenoside compound-K attenuates OVX-induced osteoporosis via the suppression of RANKL-induced osteoclastogenesis and oxidative stress
title_fullStr Ginsenoside compound-K attenuates OVX-induced osteoporosis via the suppression of RANKL-induced osteoclastogenesis and oxidative stress
title_full_unstemmed Ginsenoside compound-K attenuates OVX-induced osteoporosis via the suppression of RANKL-induced osteoclastogenesis and oxidative stress
title_short Ginsenoside compound-K attenuates OVX-induced osteoporosis via the suppression of RANKL-induced osteoclastogenesis and oxidative stress
title_sort ginsenoside compound-k attenuates ovx-induced osteoporosis via the suppression of rankl-induced osteoclastogenesis and oxidative stress
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632357/
https://www.ncbi.nlm.nih.gov/pubmed/37940733
http://dx.doi.org/10.1007/s13659-023-00405-z
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