Cell-free biosynthesis combined with deep learning accelerates de novo-development of antimicrobial peptides

Bioactive peptides are key molecules in health and medicine. Deep learning holds a big promise for the discovery and design of bioactive peptides. Yet, suitable experimental approaches are required to validate candidates in high throughput and at low cost. Here, we established a cell-free protein sy...

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Detalles Bibliográficos
Autores principales: Pandi, Amir, Adam, David, Zare, Amir, Trinh, Van Tuan, Schaefer, Stefan L., Burt, Marie, Klabunde, Björn, Bobkova, Elizaveta, Kushwaha, Manish, Foroughijabbari, Yeganeh, Braun, Peter, Spahn, Christoph, Preußer, Christian, Pogge von Strandmann, Elke, Bode, Helge B., von Buttlar, Heiner, Bertrams, Wilhelm, Jung, Anna Lena, Abendroth, Frank, Schmeck, Bernd, Hummer, Gerhard, Vázquez, Olalla, Erb, Tobias J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632401/
https://www.ncbi.nlm.nih.gov/pubmed/37938588
http://dx.doi.org/10.1038/s41467-023-42434-9

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