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The impact of brain lesions on tDCS-induced electric fields

Transcranial direct current stimulation (tDCS) can enhance motor and language rehabilitation after stroke. Though brain lesions distort tDCS-induced electric field (E-field), systematic accounts remain limited. Using electric field modelling, we investigated the effect of 630 synthetic lesions on E-...

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Autores principales: Evans, Carys, Johnstone, Ainslie, Zich, Catharina, Lee, Jenny S. A., Ward, Nick S., Bestmann, Sven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632455/
https://www.ncbi.nlm.nih.gov/pubmed/37940660
http://dx.doi.org/10.1038/s41598-023-45905-7
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author Evans, Carys
Johnstone, Ainslie
Zich, Catharina
Lee, Jenny S. A.
Ward, Nick S.
Bestmann, Sven
author_facet Evans, Carys
Johnstone, Ainslie
Zich, Catharina
Lee, Jenny S. A.
Ward, Nick S.
Bestmann, Sven
author_sort Evans, Carys
collection PubMed
description Transcranial direct current stimulation (tDCS) can enhance motor and language rehabilitation after stroke. Though brain lesions distort tDCS-induced electric field (E-field), systematic accounts remain limited. Using electric field modelling, we investigated the effect of 630 synthetic lesions on E-field magnitude in the region of interest (ROI). Models were conducted for two tDCS montages targeting either primary motor cortex (M1) or Broca’s area (BA44). Absolute E-field magnitude in the ROI differed by up to 42% compared to the non-lesioned brain depending on lesion size, lesion-ROI distance, and lesion conductivity value. Lesion location determined the sign of this difference: lesions in-line with the predominant direction of current increased E-field magnitude in the ROI, whereas lesions located in the opposite direction decreased E-field magnitude. We further explored how individualised tDCS can control lesion-induced effects on E-field. Lesions affected the individualised electrode configuration needed to maximise E-field magnitude in the ROI, but this effect was negligible when prioritising the maximisation of radial inward current. Lesions distorting tDCS-induced E-field, is likely to exacerbate inter-individual variability in E-field magnitude. Individualising electrode configuration and stimulator output can minimise lesion-induced variability but requires improved estimates of lesion conductivity. Individualised tDCS is critical to overcome E-field variability in lesioned brains.
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spelling pubmed-106324552023-11-10 The impact of brain lesions on tDCS-induced electric fields Evans, Carys Johnstone, Ainslie Zich, Catharina Lee, Jenny S. A. Ward, Nick S. Bestmann, Sven Sci Rep Article Transcranial direct current stimulation (tDCS) can enhance motor and language rehabilitation after stroke. Though brain lesions distort tDCS-induced electric field (E-field), systematic accounts remain limited. Using electric field modelling, we investigated the effect of 630 synthetic lesions on E-field magnitude in the region of interest (ROI). Models were conducted for two tDCS montages targeting either primary motor cortex (M1) or Broca’s area (BA44). Absolute E-field magnitude in the ROI differed by up to 42% compared to the non-lesioned brain depending on lesion size, lesion-ROI distance, and lesion conductivity value. Lesion location determined the sign of this difference: lesions in-line with the predominant direction of current increased E-field magnitude in the ROI, whereas lesions located in the opposite direction decreased E-field magnitude. We further explored how individualised tDCS can control lesion-induced effects on E-field. Lesions affected the individualised electrode configuration needed to maximise E-field magnitude in the ROI, but this effect was negligible when prioritising the maximisation of radial inward current. Lesions distorting tDCS-induced E-field, is likely to exacerbate inter-individual variability in E-field magnitude. Individualising electrode configuration and stimulator output can minimise lesion-induced variability but requires improved estimates of lesion conductivity. Individualised tDCS is critical to overcome E-field variability in lesioned brains. Nature Publishing Group UK 2023-11-08 /pmc/articles/PMC10632455/ /pubmed/37940660 http://dx.doi.org/10.1038/s41598-023-45905-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Evans, Carys
Johnstone, Ainslie
Zich, Catharina
Lee, Jenny S. A.
Ward, Nick S.
Bestmann, Sven
The impact of brain lesions on tDCS-induced electric fields
title The impact of brain lesions on tDCS-induced electric fields
title_full The impact of brain lesions on tDCS-induced electric fields
title_fullStr The impact of brain lesions on tDCS-induced electric fields
title_full_unstemmed The impact of brain lesions on tDCS-induced electric fields
title_short The impact of brain lesions on tDCS-induced electric fields
title_sort impact of brain lesions on tdcs-induced electric fields
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632455/
https://www.ncbi.nlm.nih.gov/pubmed/37940660
http://dx.doi.org/10.1038/s41598-023-45905-7
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