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AML with complex karyotype: extreme genomic complexity revealed by combined long-read sequencing and Hi-C technology

Acute myeloid leukemia with complex karyotype (CK-AML) is associated with poor prognosis, which is only in part explained by underlying TP53 mutations. Especially in the presence of complex chromosomal rearrangements, such as chromothripsis, the outcome of CK-AML is dismal. However, this degree of c...

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Detalles Bibliográficos
Autores principales:	Klever, Marius-Konstantin, Sträng, Eric, Hetzel, Sara, Jungnitsch, Julius, Dolnik, Anna, Schöpflin, Robert, Schrezenmeier, Jens-Florian, Schick, Felix, Blau, Olga, Westermann, Jörg, Rücker, Frank G., Xia, Zuyao, Döhner, Konstanze, Schrezenmeier, Hubert, Spielmann, Malte, Meissner, Alexander, Melo, Uirá Souto, Mundlos, Stefan, Bullinger, Lars
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society of Hematology 2023
Materias:	Myeloid Neoplasia
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632680/ https://www.ncbi.nlm.nih.gov/pubmed/37582288 http://dx.doi.org/10.1182/bloodadvances.2023010887

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