Rapid assembly of structurally diverse cyanamides and disulfanes via base-mediated aminoalkylation of aryl thiourea

A general method for the preparation of cyanamides and disulfanes from aryl thiourea and halide through a base-mediated strategy is described. Mercaptan and N-aryl cyanamide are the key intermediates in the reaction. The current method is convenient, eco-friendly, and has high yields for the synthes...

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Autores principales: Zheng, Yongpeng, Li, Jianxiao, Qi, Chaorong, Wu, Wanqing, Jiang, Huanfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632727/
https://www.ncbi.nlm.nih.gov/pubmed/37954416
http://dx.doi.org/10.1039/d3ra06051a
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author Zheng, Yongpeng
Li, Jianxiao
Qi, Chaorong
Wu, Wanqing
Jiang, Huanfeng
author_facet Zheng, Yongpeng
Li, Jianxiao
Qi, Chaorong
Wu, Wanqing
Jiang, Huanfeng
author_sort Zheng, Yongpeng
collection PubMed
description A general method for the preparation of cyanamides and disulfanes from aryl thiourea and halide through a base-mediated strategy is described. Mercaptan and N-aryl cyanamide are the key intermediates in the reaction. The current method is convenient, eco-friendly, and has high yields for the synthesis of substituted cyanamide and functional disulfanes in a one-pot procedure from readily available starting materials.
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spelling pubmed-106327272023-11-10 Rapid assembly of structurally diverse cyanamides and disulfanes via base-mediated aminoalkylation of aryl thiourea Zheng, Yongpeng Li, Jianxiao Qi, Chaorong Wu, Wanqing Jiang, Huanfeng RSC Adv Chemistry A general method for the preparation of cyanamides and disulfanes from aryl thiourea and halide through a base-mediated strategy is described. Mercaptan and N-aryl cyanamide are the key intermediates in the reaction. The current method is convenient, eco-friendly, and has high yields for the synthesis of substituted cyanamide and functional disulfanes in a one-pot procedure from readily available starting materials. The Royal Society of Chemistry 2023-11-09 /pmc/articles/PMC10632727/ /pubmed/37954416 http://dx.doi.org/10.1039/d3ra06051a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Zheng, Yongpeng
Li, Jianxiao
Qi, Chaorong
Wu, Wanqing
Jiang, Huanfeng
Rapid assembly of structurally diverse cyanamides and disulfanes via base-mediated aminoalkylation of aryl thiourea
title Rapid assembly of structurally diverse cyanamides and disulfanes via base-mediated aminoalkylation of aryl thiourea
title_full Rapid assembly of structurally diverse cyanamides and disulfanes via base-mediated aminoalkylation of aryl thiourea
title_fullStr Rapid assembly of structurally diverse cyanamides and disulfanes via base-mediated aminoalkylation of aryl thiourea
title_full_unstemmed Rapid assembly of structurally diverse cyanamides and disulfanes via base-mediated aminoalkylation of aryl thiourea
title_short Rapid assembly of structurally diverse cyanamides and disulfanes via base-mediated aminoalkylation of aryl thiourea
title_sort rapid assembly of structurally diverse cyanamides and disulfanes via base-mediated aminoalkylation of aryl thiourea
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632727/
https://www.ncbi.nlm.nih.gov/pubmed/37954416
http://dx.doi.org/10.1039/d3ra06051a
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