Cargando…

Star Polymer-Based Nanodelivery System for Pesticides: Enhanced Broad-Spectrum Toxicity and Selective Toxicity

[Image: see text] The application of nanotechnology in agriculture can break through many traditional problems of synthetic pesticides, especially for increasing bioactivity and reducing application amount. However, the safety and selective toxicity of nanocarrier-loaded pesticides should be clarifi...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Yuanrui, Wei, Ying, Yin, Meizhen, Shen, Jie, Du, Xiangge, Yan, Shuo, Dong, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10633828/
https://www.ncbi.nlm.nih.gov/pubmed/37970005
http://dx.doi.org/10.1021/acsomega.3c05722
_version_ 1785146170095435776
author Liu, Yuanrui
Wei, Ying
Yin, Meizhen
Shen, Jie
Du, Xiangge
Yan, Shuo
Dong, Min
author_facet Liu, Yuanrui
Wei, Ying
Yin, Meizhen
Shen, Jie
Du, Xiangge
Yan, Shuo
Dong, Min
author_sort Liu, Yuanrui
collection PubMed
description [Image: see text] The application of nanotechnology in agriculture can break through many traditional problems of synthetic pesticides, especially for increasing bioactivity and reducing application amount. However, the safety and selective toxicity of nanocarrier-loaded pesticides should be clarified toward natural predators. In this context, an efficient spirotetramat nanodelivery system was successfully constructed based on a star polymer (SPc). Spirotetramat could complex with SPc through hydrogen bonding and van der Waals forces spontaneously. The self-assembly of the spirotetramat/SPc complex decreased the particle size of spirotetramat from 1292 to 710 nm. After the complexation with SPc, the lethal concentration 50 (LC(50)) values of spirotratemat decreased from 252.064 to 108.871 and 332.079 to 189.257 mg/L toward target pest Frankliniella occidentalis and nontarget predator Orius sauteri with the synergic ratios of 2.315 and 1.755, respectively. The possible reason might be due to the enhancement of the broad-spectrum toxicity of SPc-loaded pesticides. Importantly, the selective toxicity ratio (STR) of spirotetramat increased from 1.32 to 1.73 with the help of SPc, indicating the higher selectivity of the spirotratemat/SPc complex toward predators. Meanwhile, the safety coefficient (SC) of spirotratemat was not significantly changed after complexation with SPc, and the spirotratemat/SPc complex belonged to the medium risk pesticide. Overall, the assembly with SPc could not only improve the control efficacy of spirotetramat but also increase its selectivity as well as alleviate its negative effects on predators. The current study is beneficial for understanding the enhancement of broad-spectrum toxicity and the selective toxicity of nanocarrier-loaded pesticides.
format Online
Article
Text
id pubmed-10633828
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-106338282023-11-15 Star Polymer-Based Nanodelivery System for Pesticides: Enhanced Broad-Spectrum Toxicity and Selective Toxicity Liu, Yuanrui Wei, Ying Yin, Meizhen Shen, Jie Du, Xiangge Yan, Shuo Dong, Min ACS Omega [Image: see text] The application of nanotechnology in agriculture can break through many traditional problems of synthetic pesticides, especially for increasing bioactivity and reducing application amount. However, the safety and selective toxicity of nanocarrier-loaded pesticides should be clarified toward natural predators. In this context, an efficient spirotetramat nanodelivery system was successfully constructed based on a star polymer (SPc). Spirotetramat could complex with SPc through hydrogen bonding and van der Waals forces spontaneously. The self-assembly of the spirotetramat/SPc complex decreased the particle size of spirotetramat from 1292 to 710 nm. After the complexation with SPc, the lethal concentration 50 (LC(50)) values of spirotratemat decreased from 252.064 to 108.871 and 332.079 to 189.257 mg/L toward target pest Frankliniella occidentalis and nontarget predator Orius sauteri with the synergic ratios of 2.315 and 1.755, respectively. The possible reason might be due to the enhancement of the broad-spectrum toxicity of SPc-loaded pesticides. Importantly, the selective toxicity ratio (STR) of spirotetramat increased from 1.32 to 1.73 with the help of SPc, indicating the higher selectivity of the spirotratemat/SPc complex toward predators. Meanwhile, the safety coefficient (SC) of spirotratemat was not significantly changed after complexation with SPc, and the spirotratemat/SPc complex belonged to the medium risk pesticide. Overall, the assembly with SPc could not only improve the control efficacy of spirotetramat but also increase its selectivity as well as alleviate its negative effects on predators. The current study is beneficial for understanding the enhancement of broad-spectrum toxicity and the selective toxicity of nanocarrier-loaded pesticides. American Chemical Society 2023-10-25 /pmc/articles/PMC10633828/ /pubmed/37970005 http://dx.doi.org/10.1021/acsomega.3c05722 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Liu, Yuanrui
Wei, Ying
Yin, Meizhen
Shen, Jie
Du, Xiangge
Yan, Shuo
Dong, Min
Star Polymer-Based Nanodelivery System for Pesticides: Enhanced Broad-Spectrum Toxicity and Selective Toxicity
title Star Polymer-Based Nanodelivery System for Pesticides: Enhanced Broad-Spectrum Toxicity and Selective Toxicity
title_full Star Polymer-Based Nanodelivery System for Pesticides: Enhanced Broad-Spectrum Toxicity and Selective Toxicity
title_fullStr Star Polymer-Based Nanodelivery System for Pesticides: Enhanced Broad-Spectrum Toxicity and Selective Toxicity
title_full_unstemmed Star Polymer-Based Nanodelivery System for Pesticides: Enhanced Broad-Spectrum Toxicity and Selective Toxicity
title_short Star Polymer-Based Nanodelivery System for Pesticides: Enhanced Broad-Spectrum Toxicity and Selective Toxicity
title_sort star polymer-based nanodelivery system for pesticides: enhanced broad-spectrum toxicity and selective toxicity
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10633828/
https://www.ncbi.nlm.nih.gov/pubmed/37970005
http://dx.doi.org/10.1021/acsomega.3c05722
work_keys_str_mv AT liuyuanrui starpolymerbasednanodeliverysystemforpesticidesenhancedbroadspectrumtoxicityandselectivetoxicity
AT weiying starpolymerbasednanodeliverysystemforpesticidesenhancedbroadspectrumtoxicityandselectivetoxicity
AT yinmeizhen starpolymerbasednanodeliverysystemforpesticidesenhancedbroadspectrumtoxicityandselectivetoxicity
AT shenjie starpolymerbasednanodeliverysystemforpesticidesenhancedbroadspectrumtoxicityandselectivetoxicity
AT duxiangge starpolymerbasednanodeliverysystemforpesticidesenhancedbroadspectrumtoxicityandselectivetoxicity
AT yanshuo starpolymerbasednanodeliverysystemforpesticidesenhancedbroadspectrumtoxicityandselectivetoxicity
AT dongmin starpolymerbasednanodeliverysystemforpesticidesenhancedbroadspectrumtoxicityandselectivetoxicity