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Star Polymer-Based Nanodelivery System for Pesticides: Enhanced Broad-Spectrum Toxicity and Selective Toxicity
[Image: see text] The application of nanotechnology in agriculture can break through many traditional problems of synthetic pesticides, especially for increasing bioactivity and reducing application amount. However, the safety and selective toxicity of nanocarrier-loaded pesticides should be clarifi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10633828/ https://www.ncbi.nlm.nih.gov/pubmed/37970005 http://dx.doi.org/10.1021/acsomega.3c05722 |
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author | Liu, Yuanrui Wei, Ying Yin, Meizhen Shen, Jie Du, Xiangge Yan, Shuo Dong, Min |
author_facet | Liu, Yuanrui Wei, Ying Yin, Meizhen Shen, Jie Du, Xiangge Yan, Shuo Dong, Min |
author_sort | Liu, Yuanrui |
collection | PubMed |
description | [Image: see text] The application of nanotechnology in agriculture can break through many traditional problems of synthetic pesticides, especially for increasing bioactivity and reducing application amount. However, the safety and selective toxicity of nanocarrier-loaded pesticides should be clarified toward natural predators. In this context, an efficient spirotetramat nanodelivery system was successfully constructed based on a star polymer (SPc). Spirotetramat could complex with SPc through hydrogen bonding and van der Waals forces spontaneously. The self-assembly of the spirotetramat/SPc complex decreased the particle size of spirotetramat from 1292 to 710 nm. After the complexation with SPc, the lethal concentration 50 (LC(50)) values of spirotratemat decreased from 252.064 to 108.871 and 332.079 to 189.257 mg/L toward target pest Frankliniella occidentalis and nontarget predator Orius sauteri with the synergic ratios of 2.315 and 1.755, respectively. The possible reason might be due to the enhancement of the broad-spectrum toxicity of SPc-loaded pesticides. Importantly, the selective toxicity ratio (STR) of spirotetramat increased from 1.32 to 1.73 with the help of SPc, indicating the higher selectivity of the spirotratemat/SPc complex toward predators. Meanwhile, the safety coefficient (SC) of spirotratemat was not significantly changed after complexation with SPc, and the spirotratemat/SPc complex belonged to the medium risk pesticide. Overall, the assembly with SPc could not only improve the control efficacy of spirotetramat but also increase its selectivity as well as alleviate its negative effects on predators. The current study is beneficial for understanding the enhancement of broad-spectrum toxicity and the selective toxicity of nanocarrier-loaded pesticides. |
format | Online Article Text |
id | pubmed-10633828 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-106338282023-11-15 Star Polymer-Based Nanodelivery System for Pesticides: Enhanced Broad-Spectrum Toxicity and Selective Toxicity Liu, Yuanrui Wei, Ying Yin, Meizhen Shen, Jie Du, Xiangge Yan, Shuo Dong, Min ACS Omega [Image: see text] The application of nanotechnology in agriculture can break through many traditional problems of synthetic pesticides, especially for increasing bioactivity and reducing application amount. However, the safety and selective toxicity of nanocarrier-loaded pesticides should be clarified toward natural predators. In this context, an efficient spirotetramat nanodelivery system was successfully constructed based on a star polymer (SPc). Spirotetramat could complex with SPc through hydrogen bonding and van der Waals forces spontaneously. The self-assembly of the spirotetramat/SPc complex decreased the particle size of spirotetramat from 1292 to 710 nm. After the complexation with SPc, the lethal concentration 50 (LC(50)) values of spirotratemat decreased from 252.064 to 108.871 and 332.079 to 189.257 mg/L toward target pest Frankliniella occidentalis and nontarget predator Orius sauteri with the synergic ratios of 2.315 and 1.755, respectively. The possible reason might be due to the enhancement of the broad-spectrum toxicity of SPc-loaded pesticides. Importantly, the selective toxicity ratio (STR) of spirotetramat increased from 1.32 to 1.73 with the help of SPc, indicating the higher selectivity of the spirotratemat/SPc complex toward predators. Meanwhile, the safety coefficient (SC) of spirotratemat was not significantly changed after complexation with SPc, and the spirotratemat/SPc complex belonged to the medium risk pesticide. Overall, the assembly with SPc could not only improve the control efficacy of spirotetramat but also increase its selectivity as well as alleviate its negative effects on predators. The current study is beneficial for understanding the enhancement of broad-spectrum toxicity and the selective toxicity of nanocarrier-loaded pesticides. American Chemical Society 2023-10-25 /pmc/articles/PMC10633828/ /pubmed/37970005 http://dx.doi.org/10.1021/acsomega.3c05722 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Liu, Yuanrui Wei, Ying Yin, Meizhen Shen, Jie Du, Xiangge Yan, Shuo Dong, Min Star Polymer-Based Nanodelivery System for Pesticides: Enhanced Broad-Spectrum Toxicity and Selective Toxicity |
title | Star Polymer-Based
Nanodelivery System for Pesticides:
Enhanced Broad-Spectrum Toxicity and Selective Toxicity |
title_full | Star Polymer-Based
Nanodelivery System for Pesticides:
Enhanced Broad-Spectrum Toxicity and Selective Toxicity |
title_fullStr | Star Polymer-Based
Nanodelivery System for Pesticides:
Enhanced Broad-Spectrum Toxicity and Selective Toxicity |
title_full_unstemmed | Star Polymer-Based
Nanodelivery System for Pesticides:
Enhanced Broad-Spectrum Toxicity and Selective Toxicity |
title_short | Star Polymer-Based
Nanodelivery System for Pesticides:
Enhanced Broad-Spectrum Toxicity and Selective Toxicity |
title_sort | star polymer-based
nanodelivery system for pesticides:
enhanced broad-spectrum toxicity and selective toxicity |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10633828/ https://www.ncbi.nlm.nih.gov/pubmed/37970005 http://dx.doi.org/10.1021/acsomega.3c05722 |
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