Characterization of intrinsic and effective fitness changes caused by temporarily fixed mutations in the SARS-CoV-2 spike E484 epitope and identification of an epistatic precondition for the evolution of E484A in variant Omicron

BACKGROUND: Intrinsic fitness costs are likely to have guided the selection of lineage-determining mutations during emergence of variants of SARS-CoV-2. Whereas changes in receptor affinity and antibody neutralization have been thoroughly mapped for individual mutations in spike, their influence on...

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Detalles Bibliográficos
Autores principales: Schröder, Simon, Richter, Anja, Veith, Talitha, Emanuel, Jackson, Gudermann, Luca, Friedmann, Kirstin, Jeworowski, Lara M., Mühlemann, Barbara, Jones, Terry C., Müller, Marcel A., Corman, Victor M., Drosten, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10633978/
https://www.ncbi.nlm.nih.gov/pubmed/37940989
http://dx.doi.org/10.1186/s12985-023-02154-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10633978/
https://www.ncbi.nlm.nih.gov/pubmed/37940989
http://dx.doi.org/10.1186/s12985-023-02154-4

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