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AMPK activator-treated human cardiac spheres enhance maturation and enable pathological modeling

BACKGROUND: Cardiac pathological outcome of metabolic remodeling is difficult to model using cardiomyocytes derived from human-induced pluripotent stem cells (hiPSC-CMs) due to low metabolic maturation. METHODS: hiPSC-CM spheres were treated with AMP-activated protein kinase (AMPK) activators and ex...

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Detalles Bibliográficos
Autores principales:	Li, Dong, Armand, Lawrence C., Sun, Fangxu, Hwang, Hyun, Wolfson, David, Rampoldi, Antonio, Liu, Rui, Forghani, Parvin, Hu, Xin, Yu, Wen-Mei, Qu, Cheng-Kui, Jones, Dean P., Wu, Ronghu, Cho, Hee Cheol, Maxwell, Joshua T., Xu, Chunhui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10633979/ https://www.ncbi.nlm.nih.gov/pubmed/37941041 http://dx.doi.org/10.1186/s13287-023-03554-7

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