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Quantitative assessment of asbestos fibers in some normal and pathological extra-abdominal tissues—a scoping review
ABSTRACT: BACKGROUND: Asbestos is a mineral present in nature and it has been used for years in numerous settings. Asbestos enters the bloodstream and lymphatic system mainly through breathing. OBJECTIVES: Studies with asbestos fiber’s quantification in human tissues are scarce except for the lung....
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634162/ https://www.ncbi.nlm.nih.gov/pubmed/37946239 http://dx.doi.org/10.1186/s12995-023-00392-4 |
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author | Graziosi, Francesca Caffaro, Paola Bonetti, Mattia Roccuzzo, Francesco Rota, Samantha Boffetta, Paolo Caraballo-Arias, Yohama Auxiliadora Zunarelli, Carlotta Danilevskaia, Nataliia Violante, Francesco Saverio |
author_facet | Graziosi, Francesca Caffaro, Paola Bonetti, Mattia Roccuzzo, Francesco Rota, Samantha Boffetta, Paolo Caraballo-Arias, Yohama Auxiliadora Zunarelli, Carlotta Danilevskaia, Nataliia Violante, Francesco Saverio |
author_sort | Graziosi, Francesca |
collection | PubMed |
description | ABSTRACT: BACKGROUND: Asbestos is a mineral present in nature and it has been used for years in numerous settings. Asbestos enters the bloodstream and lymphatic system mainly through breathing. OBJECTIVES: Studies with asbestos fiber’s quantification in human tissues are scarce except for the lung. This article summarizes asbestos studies in some extra-abdominal tissues. METHODS: A scoping review of articles that quantified asbestos fibers in extra-abdominal tissues (lymph nodes, pharynx, larynx, trachea, heart) by electron microscopy (Scanning—SEM or Transmission—TEM) was performed. RESULTS: The 10 studies selected comprised 52 cases, out of whom 108 samples were analyzed. Mostly samples were lymph node tissues (102), followed by larynx (3) and myocardium (3). No studies were found that determined the presence of asbestos in the pharynx or trachea. The concentration of asbestos fibers detected in the lymph nodes was from 0.003 million fibers per gram of dry tissue (mfgdt) up to 7400 mfgdt, in the larynx the range was from 0.5 mfgdt up to 3.6 mfgdt, in myocardium no asbestos fibers were detected. DISCUSSION: The studies included were heterogeneous in terms of case and sample characteristics and analytical techniques. As subjects exposed to asbestos are often positive for fibers in thoracic lymph nodes, we suggest that whenever a human tissue sample is analyzed for asbestos presence, the relevant draining lymph node should be concomitantly studied. |
format | Online Article Text |
id | pubmed-10634162 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-106341622023-11-10 Quantitative assessment of asbestos fibers in some normal and pathological extra-abdominal tissues—a scoping review Graziosi, Francesca Caffaro, Paola Bonetti, Mattia Roccuzzo, Francesco Rota, Samantha Boffetta, Paolo Caraballo-Arias, Yohama Auxiliadora Zunarelli, Carlotta Danilevskaia, Nataliia Violante, Francesco Saverio J Occup Med Toxicol Review ABSTRACT: BACKGROUND: Asbestos is a mineral present in nature and it has been used for years in numerous settings. Asbestos enters the bloodstream and lymphatic system mainly through breathing. OBJECTIVES: Studies with asbestos fiber’s quantification in human tissues are scarce except for the lung. This article summarizes asbestos studies in some extra-abdominal tissues. METHODS: A scoping review of articles that quantified asbestos fibers in extra-abdominal tissues (lymph nodes, pharynx, larynx, trachea, heart) by electron microscopy (Scanning—SEM or Transmission—TEM) was performed. RESULTS: The 10 studies selected comprised 52 cases, out of whom 108 samples were analyzed. Mostly samples were lymph node tissues (102), followed by larynx (3) and myocardium (3). No studies were found that determined the presence of asbestos in the pharynx or trachea. The concentration of asbestos fibers detected in the lymph nodes was from 0.003 million fibers per gram of dry tissue (mfgdt) up to 7400 mfgdt, in the larynx the range was from 0.5 mfgdt up to 3.6 mfgdt, in myocardium no asbestos fibers were detected. DISCUSSION: The studies included were heterogeneous in terms of case and sample characteristics and analytical techniques. As subjects exposed to asbestos are often positive for fibers in thoracic lymph nodes, we suggest that whenever a human tissue sample is analyzed for asbestos presence, the relevant draining lymph node should be concomitantly studied. BioMed Central 2023-11-09 /pmc/articles/PMC10634162/ /pubmed/37946239 http://dx.doi.org/10.1186/s12995-023-00392-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Graziosi, Francesca Caffaro, Paola Bonetti, Mattia Roccuzzo, Francesco Rota, Samantha Boffetta, Paolo Caraballo-Arias, Yohama Auxiliadora Zunarelli, Carlotta Danilevskaia, Nataliia Violante, Francesco Saverio Quantitative assessment of asbestos fibers in some normal and pathological extra-abdominal tissues—a scoping review |
title | Quantitative assessment of asbestos fibers in some normal and pathological extra-abdominal tissues—a scoping review |
title_full | Quantitative assessment of asbestos fibers in some normal and pathological extra-abdominal tissues—a scoping review |
title_fullStr | Quantitative assessment of asbestos fibers in some normal and pathological extra-abdominal tissues—a scoping review |
title_full_unstemmed | Quantitative assessment of asbestos fibers in some normal and pathological extra-abdominal tissues—a scoping review |
title_short | Quantitative assessment of asbestos fibers in some normal and pathological extra-abdominal tissues—a scoping review |
title_sort | quantitative assessment of asbestos fibers in some normal and pathological extra-abdominal tissues—a scoping review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634162/ https://www.ncbi.nlm.nih.gov/pubmed/37946239 http://dx.doi.org/10.1186/s12995-023-00392-4 |
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