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Mean platelet volume and the association with all-cause mortality and cardiovascular mortality among incident peritoneal dialysis patients
BACKGROUND: While mean platelet volume (MPV) is linked to severity and all-cause mortality in patients with sepsis, its association with all-cause mortality and cardiovascular mortality in patients treated with peritoneal dialysis (PD) remains unknown. OBJECTIVES: The purpose of this study was to es...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634175/ https://www.ncbi.nlm.nih.gov/pubmed/37940871 http://dx.doi.org/10.1186/s12872-023-03551-x |
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author | Wang, Jianghai Ma, Xiaochen Si, Xuepeng Wu, Mingyang Han, Wang |
author_facet | Wang, Jianghai Ma, Xiaochen Si, Xuepeng Wu, Mingyang Han, Wang |
author_sort | Wang, Jianghai |
collection | PubMed |
description | BACKGROUND: While mean platelet volume (MPV) is linked to severity and all-cause mortality in patients with sepsis, its association with all-cause mortality and cardiovascular mortality in patients treated with peritoneal dialysis (PD) remains unknown. OBJECTIVES: The purpose of this study was to estimate the relationship between MPV and all-cause mortality and cardiovascular mortality among patients treated with PD. METHOD: We retrospectively collected 1322 patients treated with PD from November 1, 2005 to August 31, 2019. All-cause mortality and cardiovascular mortality was identified as the primary outcome. MPV was classified into three categories by means of X-tile software. The correlation between MPV and all-cause mortality was assessed by Cox model. Survival curves were performed by Kaplan-Meier method. RESULTS: The median follow-up period was 50 months (30–80 months), and a total of 360 deaths were recorded. With respect to all-cause mortality, patients in MVP ≥ 10.2 fL had considerably higher risk of all-cause mortality among three models (HR 0.68, 95%CI 0.56–0.84; HR 0.70, 95%CI 0.56–0.87; HR 0.73, 95%CI 0.59–0.91; respectively). Moreover, patients treated with PD, whose MVP ≥ 10.2 fL, also suffered from significantly higher risk of cardiovascular mortality in model 1, 2, and 3 (HR 0.63, 95%CI 0.46–0.85; HR 0.66, 95%CI 0.48–0.91; HR 0.69, 95%CI 0.50–0.95; respectively). CONCLUSIONS: This study indicates that MPV is independently correlated with both all-cause mortality and cardiovascular mortality in PD. |
format | Online Article Text |
id | pubmed-10634175 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-106341752023-11-10 Mean platelet volume and the association with all-cause mortality and cardiovascular mortality among incident peritoneal dialysis patients Wang, Jianghai Ma, Xiaochen Si, Xuepeng Wu, Mingyang Han, Wang BMC Cardiovasc Disord Research BACKGROUND: While mean platelet volume (MPV) is linked to severity and all-cause mortality in patients with sepsis, its association with all-cause mortality and cardiovascular mortality in patients treated with peritoneal dialysis (PD) remains unknown. OBJECTIVES: The purpose of this study was to estimate the relationship between MPV and all-cause mortality and cardiovascular mortality among patients treated with PD. METHOD: We retrospectively collected 1322 patients treated with PD from November 1, 2005 to August 31, 2019. All-cause mortality and cardiovascular mortality was identified as the primary outcome. MPV was classified into three categories by means of X-tile software. The correlation between MPV and all-cause mortality was assessed by Cox model. Survival curves were performed by Kaplan-Meier method. RESULTS: The median follow-up period was 50 months (30–80 months), and a total of 360 deaths were recorded. With respect to all-cause mortality, patients in MVP ≥ 10.2 fL had considerably higher risk of all-cause mortality among three models (HR 0.68, 95%CI 0.56–0.84; HR 0.70, 95%CI 0.56–0.87; HR 0.73, 95%CI 0.59–0.91; respectively). Moreover, patients treated with PD, whose MVP ≥ 10.2 fL, also suffered from significantly higher risk of cardiovascular mortality in model 1, 2, and 3 (HR 0.63, 95%CI 0.46–0.85; HR 0.66, 95%CI 0.48–0.91; HR 0.69, 95%CI 0.50–0.95; respectively). CONCLUSIONS: This study indicates that MPV is independently correlated with both all-cause mortality and cardiovascular mortality in PD. BioMed Central 2023-11-08 /pmc/articles/PMC10634175/ /pubmed/37940871 http://dx.doi.org/10.1186/s12872-023-03551-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Wang, Jianghai Ma, Xiaochen Si, Xuepeng Wu, Mingyang Han, Wang Mean platelet volume and the association with all-cause mortality and cardiovascular mortality among incident peritoneal dialysis patients |
title | Mean platelet volume and the association with all-cause mortality and cardiovascular mortality among incident peritoneal dialysis patients |
title_full | Mean platelet volume and the association with all-cause mortality and cardiovascular mortality among incident peritoneal dialysis patients |
title_fullStr | Mean platelet volume and the association with all-cause mortality and cardiovascular mortality among incident peritoneal dialysis patients |
title_full_unstemmed | Mean platelet volume and the association with all-cause mortality and cardiovascular mortality among incident peritoneal dialysis patients |
title_short | Mean platelet volume and the association with all-cause mortality and cardiovascular mortality among incident peritoneal dialysis patients |
title_sort | mean platelet volume and the association with all-cause mortality and cardiovascular mortality among incident peritoneal dialysis patients |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634175/ https://www.ncbi.nlm.nih.gov/pubmed/37940871 http://dx.doi.org/10.1186/s12872-023-03551-x |
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