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Pre- and post-headache phases of migraine: multi-country results from the CaMEO – International Study

BACKGROUND: Individuals with migraine frequently experience pre- and post-headache symptoms. This analysis aimed to characterize the relative frequency and burden of pre- and post-headache symptoms in people with migraine using data collected through the Chronic Migraine Epidemiology and Outcomes –...

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Autores principales: Lipton, Richard B., Lanteri-Minet, Michel, Leroux, Elizabeth, Manack Adams, Aubrey, Contreras-De Lama, Janette, Reed, Michael L., Fanning, Kristina M., Buse, Dawn C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Milan 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634176/
https://www.ncbi.nlm.nih.gov/pubmed/37940856
http://dx.doi.org/10.1186/s10194-023-01683-1
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author Lipton, Richard B.
Lanteri-Minet, Michel
Leroux, Elizabeth
Manack Adams, Aubrey
Contreras-De Lama, Janette
Reed, Michael L.
Fanning, Kristina M.
Buse, Dawn C.
author_facet Lipton, Richard B.
Lanteri-Minet, Michel
Leroux, Elizabeth
Manack Adams, Aubrey
Contreras-De Lama, Janette
Reed, Michael L.
Fanning, Kristina M.
Buse, Dawn C.
author_sort Lipton, Richard B.
collection PubMed
description BACKGROUND: Individuals with migraine frequently experience pre- and post-headache symptoms. This analysis aimed to characterize the relative frequency and burden of pre- and post-headache symptoms in people with migraine using data collected through the Chronic Migraine Epidemiology and Outcomes – International Study. METHODS: This cross-sectional, observational, web-based survey was conducted in 2021–2022 in Canada, France, Germany, Japan, the United Kingdom, and the United States. Respondents who met modified International Classification of Headache Disorders, 3rd edition, criteria were offered the opportunity to participate. Information collected included migraine-related disability, depression/anxiety symptoms, cutaneous allodynia, activity limitations, and acute treatment optimization. Respondents indicated how often they had pre- or post-headache symptoms using a 5-point scale, ranging from 0 to 4, with a rating of 2 or higher classified as a pre- or post-headache symptom case. Modeling was used to examine relationships with monthly headache days (MHDs) and activity limitations during pre-headache and post-headache phases. RESULTS: Among a total of 14,492 respondents, pre-headache symptoms were reported by 66.9%, while post-headache symptoms were reported by 60.2%. Both pre-headache and post-headache symptoms were reported by 49.5% of respondents, only pre-headache by 17.4%, only post-headache by 10.7%, and neither pre- nor post-headache symptoms by 22.4%. Compared with respondents who experienced only pre- or post-headache symptoms, respondents who experienced both pre- and post-headache symptoms had the highest rates of 4–7, 8–14, and ≥ 15 monthly headache days (23.1%, 14.1%, and 10.9%, respectively). Of respondents with both pre- and post-headache symptoms, 58.5% reported moderate-to-severe disability, 47.7% reported clinically significant symptoms of depression, 49.0% reported clinically significant symptoms of anxiety, and 63.8% reported cutaneous allodynia with headache (ASC-12). Moderate-to-severe activity limitations were reported during the pre-headache (29.5%) and post-headache phases (27.2%). For all outcomes modeled, after controlling for covariates, having pre-headache symptoms, post-headache symptoms, or both were associated with worse outcomes than having neither. CONCLUSIONS: Pre- and post-headache phases of migraine are common, carry unrecognized burden, and may be a target for treatment. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-106341762023-11-10 Pre- and post-headache phases of migraine: multi-country results from the CaMEO – International Study Lipton, Richard B. Lanteri-Minet, Michel Leroux, Elizabeth Manack Adams, Aubrey Contreras-De Lama, Janette Reed, Michael L. Fanning, Kristina M. Buse, Dawn C. J Headache Pain Research BACKGROUND: Individuals with migraine frequently experience pre- and post-headache symptoms. This analysis aimed to characterize the relative frequency and burden of pre- and post-headache symptoms in people with migraine using data collected through the Chronic Migraine Epidemiology and Outcomes – International Study. METHODS: This cross-sectional, observational, web-based survey was conducted in 2021–2022 in Canada, France, Germany, Japan, the United Kingdom, and the United States. Respondents who met modified International Classification of Headache Disorders, 3rd edition, criteria were offered the opportunity to participate. Information collected included migraine-related disability, depression/anxiety symptoms, cutaneous allodynia, activity limitations, and acute treatment optimization. Respondents indicated how often they had pre- or post-headache symptoms using a 5-point scale, ranging from 0 to 4, with a rating of 2 or higher classified as a pre- or post-headache symptom case. Modeling was used to examine relationships with monthly headache days (MHDs) and activity limitations during pre-headache and post-headache phases. RESULTS: Among a total of 14,492 respondents, pre-headache symptoms were reported by 66.9%, while post-headache symptoms were reported by 60.2%. Both pre-headache and post-headache symptoms were reported by 49.5% of respondents, only pre-headache by 17.4%, only post-headache by 10.7%, and neither pre- nor post-headache symptoms by 22.4%. Compared with respondents who experienced only pre- or post-headache symptoms, respondents who experienced both pre- and post-headache symptoms had the highest rates of 4–7, 8–14, and ≥ 15 monthly headache days (23.1%, 14.1%, and 10.9%, respectively). Of respondents with both pre- and post-headache symptoms, 58.5% reported moderate-to-severe disability, 47.7% reported clinically significant symptoms of depression, 49.0% reported clinically significant symptoms of anxiety, and 63.8% reported cutaneous allodynia with headache (ASC-12). Moderate-to-severe activity limitations were reported during the pre-headache (29.5%) and post-headache phases (27.2%). For all outcomes modeled, after controlling for covariates, having pre-headache symptoms, post-headache symptoms, or both were associated with worse outcomes than having neither. CONCLUSIONS: Pre- and post-headache phases of migraine are common, carry unrecognized burden, and may be a target for treatment. GRAPHICAL ABSTRACT: [Image: see text] Springer Milan 2023-11-08 /pmc/articles/PMC10634176/ /pubmed/37940856 http://dx.doi.org/10.1186/s10194-023-01683-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Lipton, Richard B.
Lanteri-Minet, Michel
Leroux, Elizabeth
Manack Adams, Aubrey
Contreras-De Lama, Janette
Reed, Michael L.
Fanning, Kristina M.
Buse, Dawn C.
Pre- and post-headache phases of migraine: multi-country results from the CaMEO – International Study
title Pre- and post-headache phases of migraine: multi-country results from the CaMEO – International Study
title_full Pre- and post-headache phases of migraine: multi-country results from the CaMEO – International Study
title_fullStr Pre- and post-headache phases of migraine: multi-country results from the CaMEO – International Study
title_full_unstemmed Pre- and post-headache phases of migraine: multi-country results from the CaMEO – International Study
title_short Pre- and post-headache phases of migraine: multi-country results from the CaMEO – International Study
title_sort pre- and post-headache phases of migraine: multi-country results from the cameo – international study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634176/
https://www.ncbi.nlm.nih.gov/pubmed/37940856
http://dx.doi.org/10.1186/s10194-023-01683-1
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