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Case Report: Radiation necrosis mimicking tumor progression in a patient with extranodal natural killer/T-cell lymphoma

Radiation-induced cerebral necrosis, also known as radiation encephalopathy, is a debilitating condition that significantly impacts the quality of life for affected patients. Secondary central nervous system lymphoma (SCNSL) typically arises from highly aggressive mature B-cell lymphoma, but rarely...

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Autores principales: Chen, Boxiao, Fan, Yili, Wang, Luyao, Zhang, Jiawei, Xin, Dijia, Qiu, Xi, Jiang, Huawei, Li, Baizhou, Chen, Qin, Wang, Chao, Xiao, Xibin, Huang, Liansheng, Xu, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634224/
https://www.ncbi.nlm.nih.gov/pubmed/37954919
http://dx.doi.org/10.3389/fradi.2023.1257565
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author Chen, Boxiao
Fan, Yili
Wang, Luyao
Zhang, Jiawei
Xin, Dijia
Qiu, Xi
Jiang, Huawei
Li, Baizhou
Chen, Qin
Wang, Chao
Xiao, Xibin
Huang, Liansheng
Xu, Yang
author_facet Chen, Boxiao
Fan, Yili
Wang, Luyao
Zhang, Jiawei
Xin, Dijia
Qiu, Xi
Jiang, Huawei
Li, Baizhou
Chen, Qin
Wang, Chao
Xiao, Xibin
Huang, Liansheng
Xu, Yang
author_sort Chen, Boxiao
collection PubMed
description Radiation-induced cerebral necrosis, also known as radiation encephalopathy, is a debilitating condition that significantly impacts the quality of life for affected patients. Secondary central nervous system lymphoma (SCNSL) typically arises from highly aggressive mature B-cell lymphoma, but rarely from extranodal natural killer T-cell lymphoma (ENKTL). Treatment will be guided by differentiation between lymphoma progression from brain necrosis, and is particularly important for critically ill patients in an acute setting. However, differential diagnosis remains challenging because they share similar clinical manifestations and have no specific imaging features. We present the case of a 52-year-old man with ENKTL who suffered an emergency brain herniation secondary to massive radiation necrosis. The diagnosis established by brain biopsy ultimately led to appropriate treatment. The importance of the diagnostic biopsy is highlighted in this case for distinguishing between radiation necrosis and SCNSL.
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spelling pubmed-106342242023-11-10 Case Report: Radiation necrosis mimicking tumor progression in a patient with extranodal natural killer/T-cell lymphoma Chen, Boxiao Fan, Yili Wang, Luyao Zhang, Jiawei Xin, Dijia Qiu, Xi Jiang, Huawei Li, Baizhou Chen, Qin Wang, Chao Xiao, Xibin Huang, Liansheng Xu, Yang Front Radiol Radiology Radiation-induced cerebral necrosis, also known as radiation encephalopathy, is a debilitating condition that significantly impacts the quality of life for affected patients. Secondary central nervous system lymphoma (SCNSL) typically arises from highly aggressive mature B-cell lymphoma, but rarely from extranodal natural killer T-cell lymphoma (ENKTL). Treatment will be guided by differentiation between lymphoma progression from brain necrosis, and is particularly important for critically ill patients in an acute setting. However, differential diagnosis remains challenging because they share similar clinical manifestations and have no specific imaging features. We present the case of a 52-year-old man with ENKTL who suffered an emergency brain herniation secondary to massive radiation necrosis. The diagnosis established by brain biopsy ultimately led to appropriate treatment. The importance of the diagnostic biopsy is highlighted in this case for distinguishing between radiation necrosis and SCNSL. Frontiers Media S.A. 2023-10-25 /pmc/articles/PMC10634224/ /pubmed/37954919 http://dx.doi.org/10.3389/fradi.2023.1257565 Text en © 2023 Chen, Fan, Wang, Zhang, Xin, Qiu, Jiang, Li, Chen, Wang, Xiao, Huang and Xu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Radiology
Chen, Boxiao
Fan, Yili
Wang, Luyao
Zhang, Jiawei
Xin, Dijia
Qiu, Xi
Jiang, Huawei
Li, Baizhou
Chen, Qin
Wang, Chao
Xiao, Xibin
Huang, Liansheng
Xu, Yang
Case Report: Radiation necrosis mimicking tumor progression in a patient with extranodal natural killer/T-cell lymphoma
title Case Report: Radiation necrosis mimicking tumor progression in a patient with extranodal natural killer/T-cell lymphoma
title_full Case Report: Radiation necrosis mimicking tumor progression in a patient with extranodal natural killer/T-cell lymphoma
title_fullStr Case Report: Radiation necrosis mimicking tumor progression in a patient with extranodal natural killer/T-cell lymphoma
title_full_unstemmed Case Report: Radiation necrosis mimicking tumor progression in a patient with extranodal natural killer/T-cell lymphoma
title_short Case Report: Radiation necrosis mimicking tumor progression in a patient with extranodal natural killer/T-cell lymphoma
title_sort case report: radiation necrosis mimicking tumor progression in a patient with extranodal natural killer/t-cell lymphoma
topic Radiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634224/
https://www.ncbi.nlm.nih.gov/pubmed/37954919
http://dx.doi.org/10.3389/fradi.2023.1257565
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