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Dysregulated neuromodulation in the anterior cingulate cortex in chronic pain

Chronic pain is a significant global socioeconomic burden with limited long-term treatment options. The intractable nature of chronic pain stems from two primary factors: the multifaceted nature of pain itself and an insufficient understanding of the diverse physiological mechanisms that underlie it...

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Autores principales: Lançon, Kevin, Séguéla, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634228/
https://www.ncbi.nlm.nih.gov/pubmed/37954846
http://dx.doi.org/10.3389/fphar.2023.1289218
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author Lançon, Kevin
Séguéla, Philippe
author_facet Lançon, Kevin
Séguéla, Philippe
author_sort Lançon, Kevin
collection PubMed
description Chronic pain is a significant global socioeconomic burden with limited long-term treatment options. The intractable nature of chronic pain stems from two primary factors: the multifaceted nature of pain itself and an insufficient understanding of the diverse physiological mechanisms that underlie its initiation and maintenance, in both the peripheral and central nervous systems. The development of novel non-opioidergic analgesic approaches is contingent on our ability to normalize the dysregulated nociceptive pathways involved in pathological pain processing. The anterior cingulate cortex (ACC) stands out due to its involvement in top-down modulation of pain perception, its abnormal activity in chronic pain conditions, and its contribution to cognitive functions frequently impaired in chronic pain states. Here, we review the roles of the monoamines dopamine (DA), norepinephrine (NE), serotonin (5-HT), and other neuromodulators in controlling the activity of the ACC and how chronic pain alters their signaling in ACC circuits to promote pathological hyperexcitability. Additionally, we discuss the potential of targeting these monoaminergic pathways as a therapeutic strategy for treating the cognitive and affective symptoms associated with chronic pain.
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spelling pubmed-106342282023-11-10 Dysregulated neuromodulation in the anterior cingulate cortex in chronic pain Lançon, Kevin Séguéla, Philippe Front Pharmacol Pharmacology Chronic pain is a significant global socioeconomic burden with limited long-term treatment options. The intractable nature of chronic pain stems from two primary factors: the multifaceted nature of pain itself and an insufficient understanding of the diverse physiological mechanisms that underlie its initiation and maintenance, in both the peripheral and central nervous systems. The development of novel non-opioidergic analgesic approaches is contingent on our ability to normalize the dysregulated nociceptive pathways involved in pathological pain processing. The anterior cingulate cortex (ACC) stands out due to its involvement in top-down modulation of pain perception, its abnormal activity in chronic pain conditions, and its contribution to cognitive functions frequently impaired in chronic pain states. Here, we review the roles of the monoamines dopamine (DA), norepinephrine (NE), serotonin (5-HT), and other neuromodulators in controlling the activity of the ACC and how chronic pain alters their signaling in ACC circuits to promote pathological hyperexcitability. Additionally, we discuss the potential of targeting these monoaminergic pathways as a therapeutic strategy for treating the cognitive and affective symptoms associated with chronic pain. Frontiers Media S.A. 2023-10-25 /pmc/articles/PMC10634228/ /pubmed/37954846 http://dx.doi.org/10.3389/fphar.2023.1289218 Text en Copyright © 2023 Lançon and Séguéla. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Lançon, Kevin
Séguéla, Philippe
Dysregulated neuromodulation in the anterior cingulate cortex in chronic pain
title Dysregulated neuromodulation in the anterior cingulate cortex in chronic pain
title_full Dysregulated neuromodulation in the anterior cingulate cortex in chronic pain
title_fullStr Dysregulated neuromodulation in the anterior cingulate cortex in chronic pain
title_full_unstemmed Dysregulated neuromodulation in the anterior cingulate cortex in chronic pain
title_short Dysregulated neuromodulation in the anterior cingulate cortex in chronic pain
title_sort dysregulated neuromodulation in the anterior cingulate cortex in chronic pain
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634228/
https://www.ncbi.nlm.nih.gov/pubmed/37954846
http://dx.doi.org/10.3389/fphar.2023.1289218
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