The XIST lncRNA is a sex-specific reservoir of TLR7 ligands in SLE

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with a dramatic sex bias, affecting 9 times more women than men. Activation of Toll-like receptor 7 (TLR7) by self-RNA is a central pathogenic process leading to aberrant production of type I interferon (IFN) in SLE, but the specifi...

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Detalles Bibliográficos
Autores principales: Crawford, Jonathan D., Wang, Hong, Trejo-Zambrano, Daniela, Cimbro, Raffaello, Talbot, C. Conover, Thomas, Mekha A., Curran, Ashley M., Girgis, Alexander A., Schroeder, John T., Fava, Andrea, Goldman, Daniel W., Petri, Michelle, Rosen, Antony, Antiochos, Brendan, Darrah, Erika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634230/
https://www.ncbi.nlm.nih.gov/pubmed/37733447
http://dx.doi.org/10.1172/jci.insight.169344

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