Cargando…
Microbial Primer: Multidrug efflux pumps
Multidrug efflux pumps are molecular machines that sit in the bacterial cell membrane and pump molecules out from either the periplasm or cytoplasm to outside the cell. While involved in a variety of biological roles, they are primarily known for their contribution to antibiotic resistance by limiti...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Microbiology Society
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634363/ https://www.ncbi.nlm.nih.gov/pubmed/37787650 http://dx.doi.org/10.1099/mic.0.001370 |
_version_ | 1785146204426862592 |
---|---|
author | Siasat, Pauline Ann Blair, Jessica M. A. |
author_facet | Siasat, Pauline Ann Blair, Jessica M. A. |
author_sort | Siasat, Pauline Ann |
collection | PubMed |
description | Multidrug efflux pumps are molecular machines that sit in the bacterial cell membrane and pump molecules out from either the periplasm or cytoplasm to outside the cell. While involved in a variety of biological roles, they are primarily known for their contribution to antibiotic resistance by limiting the intracellular accumulation of antimicrobial compounds within bacteria. These transporters are often overexpressed in clinical isolates, leading to multidrug-resistant phenotypes. Efflux pumps are classified into several families based on their structure and understanding the characteristics of each family is important for the development of novel therapies to restore antibiotic potency. |
format | Online Article Text |
id | pubmed-10634363 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Microbiology Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-106343632023-11-15 Microbial Primer: Multidrug efflux pumps Siasat, Pauline Ann Blair, Jessica M. A. Microbiology (Reading) Microbial Primer Multidrug efflux pumps are molecular machines that sit in the bacterial cell membrane and pump molecules out from either the periplasm or cytoplasm to outside the cell. While involved in a variety of biological roles, they are primarily known for their contribution to antibiotic resistance by limiting the intracellular accumulation of antimicrobial compounds within bacteria. These transporters are often overexpressed in clinical isolates, leading to multidrug-resistant phenotypes. Efflux pumps are classified into several families based on their structure and understanding the characteristics of each family is important for the development of novel therapies to restore antibiotic potency. Microbiology Society 2023-10-03 /pmc/articles/PMC10634363/ /pubmed/37787650 http://dx.doi.org/10.1099/mic.0.001370 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution. |
spellingShingle | Microbial Primer Siasat, Pauline Ann Blair, Jessica M. A. Microbial Primer: Multidrug efflux pumps |
title | Microbial Primer: Multidrug efflux pumps |
title_full | Microbial Primer: Multidrug efflux pumps |
title_fullStr | Microbial Primer: Multidrug efflux pumps |
title_full_unstemmed | Microbial Primer: Multidrug efflux pumps |
title_short | Microbial Primer: Multidrug efflux pumps |
title_sort | microbial primer: multidrug efflux pumps |
topic | Microbial Primer |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634363/ https://www.ncbi.nlm.nih.gov/pubmed/37787650 http://dx.doi.org/10.1099/mic.0.001370 |
work_keys_str_mv | AT siasatpaulineann microbialprimermultidrugeffluxpumps AT blairjessicama microbialprimermultidrugeffluxpumps |