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The role of oral microbiota in cancer

Cancer remains a significant global challenge, with an estimated 47% increase in cancer patients from 2020 to 2040. Increasing research has identified microorganism as a risk factor for cancer development. The oral cavity, second only to the colon, harbors more than 700 bacterial species and serves...

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Autores principales: Lan, Zhou, Liu, Wei-Jia, Cui, Hao, Zou, Ke-Long, Chen, Hao, Zhao, Yu-Yue, Yu, Guang-Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634615/
https://www.ncbi.nlm.nih.gov/pubmed/37954233
http://dx.doi.org/10.3389/fmicb.2023.1253025
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author Lan, Zhou
Liu, Wei-Jia
Cui, Hao
Zou, Ke-Long
Chen, Hao
Zhao, Yu-Yue
Yu, Guang-Tao
author_facet Lan, Zhou
Liu, Wei-Jia
Cui, Hao
Zou, Ke-Long
Chen, Hao
Zhao, Yu-Yue
Yu, Guang-Tao
author_sort Lan, Zhou
collection PubMed
description Cancer remains a significant global challenge, with an estimated 47% increase in cancer patients from 2020 to 2040. Increasing research has identified microorganism as a risk factor for cancer development. The oral cavity, second only to the colon, harbors more than 700 bacterial species and serves as a crucial microbial habitat. Although numerous epidemiological studies have reported associations between oral microorganisms and major systemic tumors, the relationship between oral microorganisms and cancers remains largely unclear. Current research primarily focuses on respiratory and digestive system tumors due to their anatomical proximity to the oral cavity. The relevant mechanism research mainly involves 47% dominant oral microbial population that can be cultured in vitro. However, further exploration is necessary to elucidate the mechanisms underlying the association between oral microbiota and tumors. This review systematically summarizes the reported correlations between oral microbiota and common cancers while also outlining potential mechanisms that may guide biological tumor treatment.
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spelling pubmed-106346152023-11-10 The role of oral microbiota in cancer Lan, Zhou Liu, Wei-Jia Cui, Hao Zou, Ke-Long Chen, Hao Zhao, Yu-Yue Yu, Guang-Tao Front Microbiol Microbiology Cancer remains a significant global challenge, with an estimated 47% increase in cancer patients from 2020 to 2040. Increasing research has identified microorganism as a risk factor for cancer development. The oral cavity, second only to the colon, harbors more than 700 bacterial species and serves as a crucial microbial habitat. Although numerous epidemiological studies have reported associations between oral microorganisms and major systemic tumors, the relationship between oral microorganisms and cancers remains largely unclear. Current research primarily focuses on respiratory and digestive system tumors due to their anatomical proximity to the oral cavity. The relevant mechanism research mainly involves 47% dominant oral microbial population that can be cultured in vitro. However, further exploration is necessary to elucidate the mechanisms underlying the association between oral microbiota and tumors. This review systematically summarizes the reported correlations between oral microbiota and common cancers while also outlining potential mechanisms that may guide biological tumor treatment. Frontiers Media S.A. 2023-10-24 /pmc/articles/PMC10634615/ /pubmed/37954233 http://dx.doi.org/10.3389/fmicb.2023.1253025 Text en Copyright © 2023 Lan, Liu, Cui, Zou, Chen, Zhao and Yu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Lan, Zhou
Liu, Wei-Jia
Cui, Hao
Zou, Ke-Long
Chen, Hao
Zhao, Yu-Yue
Yu, Guang-Tao
The role of oral microbiota in cancer
title The role of oral microbiota in cancer
title_full The role of oral microbiota in cancer
title_fullStr The role of oral microbiota in cancer
title_full_unstemmed The role of oral microbiota in cancer
title_short The role of oral microbiota in cancer
title_sort role of oral microbiota in cancer
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634615/
https://www.ncbi.nlm.nih.gov/pubmed/37954233
http://dx.doi.org/10.3389/fmicb.2023.1253025
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