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Two Cases of Frontal Variation of Idiopathic Calvarial Thinning—Therapeutic Effect of Denosumab and Romosozumab
Idiopathic calvarial thinning is a rare condition that causes progressive, painless thinning of the skull bones without systemic disease. We present 2 cases of idiopathic calvarial thinning involving the bifrontal region. Both patients exhibited forehead depression and had normal biochemical tests e...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634628/ https://www.ncbi.nlm.nih.gov/pubmed/37954836 http://dx.doi.org/10.1210/jcemcr/luad122 |
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author | Baek, Seungjin Hong, Namki Rhee, Yumie |
author_facet | Baek, Seungjin Hong, Namki Rhee, Yumie |
author_sort | Baek, Seungjin |
collection | PubMed |
description | Idiopathic calvarial thinning is a rare condition that causes progressive, painless thinning of the skull bones without systemic disease. We present 2 cases of idiopathic calvarial thinning involving the bifrontal region. Both patients exhibited forehead depression and had normal biochemical tests except for mild vitamin D deficiency. The first patient received treatment with denosumab for 3 years, showing no further progression of the skull thinning. The second patient was treated with denosumab for 3 years, followed by romosozumab for 1 year, resulting in no further progression and even slight recovery of the skull thickness. These cases demonstrate that idiopathic calvarial thinning can involve the bifrontal region and highlight the favorable treatment and prognosis with denosumab or romosozumab. |
format | Online Article Text |
id | pubmed-10634628 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-106346282023-11-10 Two Cases of Frontal Variation of Idiopathic Calvarial Thinning—Therapeutic Effect of Denosumab and Romosozumab Baek, Seungjin Hong, Namki Rhee, Yumie JCEM Case Rep Case Report Idiopathic calvarial thinning is a rare condition that causes progressive, painless thinning of the skull bones without systemic disease. We present 2 cases of idiopathic calvarial thinning involving the bifrontal region. Both patients exhibited forehead depression and had normal biochemical tests except for mild vitamin D deficiency. The first patient received treatment with denosumab for 3 years, showing no further progression of the skull thinning. The second patient was treated with denosumab for 3 years, followed by romosozumab for 1 year, resulting in no further progression and even slight recovery of the skull thickness. These cases demonstrate that idiopathic calvarial thinning can involve the bifrontal region and highlight the favorable treatment and prognosis with denosumab or romosozumab. Oxford University Press 2023-11-07 /pmc/articles/PMC10634628/ /pubmed/37954836 http://dx.doi.org/10.1210/jcemcr/luad122 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Case Report Baek, Seungjin Hong, Namki Rhee, Yumie Two Cases of Frontal Variation of Idiopathic Calvarial Thinning—Therapeutic Effect of Denosumab and Romosozumab |
title | Two Cases of Frontal Variation of Idiopathic Calvarial Thinning—Therapeutic Effect of Denosumab and Romosozumab |
title_full | Two Cases of Frontal Variation of Idiopathic Calvarial Thinning—Therapeutic Effect of Denosumab and Romosozumab |
title_fullStr | Two Cases of Frontal Variation of Idiopathic Calvarial Thinning—Therapeutic Effect of Denosumab and Romosozumab |
title_full_unstemmed | Two Cases of Frontal Variation of Idiopathic Calvarial Thinning—Therapeutic Effect of Denosumab and Romosozumab |
title_short | Two Cases of Frontal Variation of Idiopathic Calvarial Thinning—Therapeutic Effect of Denosumab and Romosozumab |
title_sort | two cases of frontal variation of idiopathic calvarial thinning—therapeutic effect of denosumab and romosozumab |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634628/ https://www.ncbi.nlm.nih.gov/pubmed/37954836 http://dx.doi.org/10.1210/jcemcr/luad122 |
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