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Fast myosin binding protein C knockout in skeletal muscle alters length-dependent activation and myofilament structure

In striated muscle, some sarcomere proteins regulate crossbridge cycling by varying the propensity of myosin heads to interact with actin. Myosin-binding protein C (MyBP-C) is bound to the myosin thick filament and is predicted to interact and stabilize myosin heads in a docked position against the...

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Detalles Bibliográficos
Autores principales: Hessel, Anthony L., Kuehn, Michel, Han, Seong-Won, Ma, Weikang, Irving, Thomas C., Momb, Brent A., Song, Taejeong, Sadayappan, Sakthivel, Linke, Wolfgang A., Palmer, Bradley M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634671/
https://www.ncbi.nlm.nih.gov/pubmed/37961718
http://dx.doi.org/10.1101/2023.10.19.563160

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