Integrated Proteomics Identifies Troponin I Isoform Switch as a Regulator of a Sarcomere-Metabolism Axis During Cardiac Regeneration

Adult mammalian cardiomyocytes have limited proliferative potential, and after myocardial infarction (MI), injured cardiac tissue is replaced with fibrotic scar rather than with functioning myocardium. In contrast, the neonatal mouse heart possesses a regenerative capacity governed by cardiomyocyte...

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Detalles Bibliográficos
Autores principales: Aballo, Timothy J., Bae, Jiyoung, Paltzer, Wyatt G., Chapman, Emily A., Salamon, Rebecca J., Mann, Morgan M., Ge, Ying, Mahmoud, Ahmed I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634731/
https://www.ncbi.nlm.nih.gov/pubmed/37961158
http://dx.doi.org/10.1101/2023.10.20.563389

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