Cargando…
Neural signatures of stress susceptibility and resilience in the amygdala-hippocampal network
The neural dynamics that underlie divergent anhedonic responses to stress remain unclear. Here, we identified neuronal dynamics in an amygdala-hippocampal circuit that distinguish stress resilience and susceptibility. In a reward-choice task, basolateral amygdala (BLA) activity in resilient mice sho...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634760/ https://www.ncbi.nlm.nih.gov/pubmed/37961124 http://dx.doi.org/10.1101/2023.10.23.563652 |
_version_ | 1785146236910698496 |
---|---|
author | Xia, Frances Fascianelli, Valeria Vishwakarma, Nina Ghinger, Frances Grace Fusi, Stefano Kheirbek, Mazen A |
author_facet | Xia, Frances Fascianelli, Valeria Vishwakarma, Nina Ghinger, Frances Grace Fusi, Stefano Kheirbek, Mazen A |
author_sort | Xia, Frances |
collection | PubMed |
description | The neural dynamics that underlie divergent anhedonic responses to stress remain unclear. Here, we identified neuronal dynamics in an amygdala-hippocampal circuit that distinguish stress resilience and susceptibility. In a reward-choice task, basolateral amygdala (BLA) activity in resilient mice showed enhanced discrimination of upcoming reward choices. In contrast, a rumination-like signature emerged in the BLA of susceptible mice; a linear decoder could classify the intention to switch or stay on a previously chosen reward. Spontaneous activity in the BLA of susceptible mice was higher dimensional than controls, reflecting the exploration of a larger number of distinct neural states. Manipulation of vCA1-BLA inputs rescued dysfunctional neural dynamics and anhedonia in susceptible mice, suggesting that targeting this pathway can enhance BLA circuit function and ameliorate of depression-related behaviors. |
format | Online Article Text |
id | pubmed-10634760 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cold Spring Harbor Laboratory |
record_format | MEDLINE/PubMed |
spelling | pubmed-106347602023-11-13 Neural signatures of stress susceptibility and resilience in the amygdala-hippocampal network Xia, Frances Fascianelli, Valeria Vishwakarma, Nina Ghinger, Frances Grace Fusi, Stefano Kheirbek, Mazen A bioRxiv Article The neural dynamics that underlie divergent anhedonic responses to stress remain unclear. Here, we identified neuronal dynamics in an amygdala-hippocampal circuit that distinguish stress resilience and susceptibility. In a reward-choice task, basolateral amygdala (BLA) activity in resilient mice showed enhanced discrimination of upcoming reward choices. In contrast, a rumination-like signature emerged in the BLA of susceptible mice; a linear decoder could classify the intention to switch or stay on a previously chosen reward. Spontaneous activity in the BLA of susceptible mice was higher dimensional than controls, reflecting the exploration of a larger number of distinct neural states. Manipulation of vCA1-BLA inputs rescued dysfunctional neural dynamics and anhedonia in susceptible mice, suggesting that targeting this pathway can enhance BLA circuit function and ameliorate of depression-related behaviors. Cold Spring Harbor Laboratory 2023-10-23 /pmc/articles/PMC10634760/ /pubmed/37961124 http://dx.doi.org/10.1101/2023.10.23.563652 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator. |
spellingShingle | Article Xia, Frances Fascianelli, Valeria Vishwakarma, Nina Ghinger, Frances Grace Fusi, Stefano Kheirbek, Mazen A Neural signatures of stress susceptibility and resilience in the amygdala-hippocampal network |
title | Neural signatures of stress susceptibility and resilience in the amygdala-hippocampal network |
title_full | Neural signatures of stress susceptibility and resilience in the amygdala-hippocampal network |
title_fullStr | Neural signatures of stress susceptibility and resilience in the amygdala-hippocampal network |
title_full_unstemmed | Neural signatures of stress susceptibility and resilience in the amygdala-hippocampal network |
title_short | Neural signatures of stress susceptibility and resilience in the amygdala-hippocampal network |
title_sort | neural signatures of stress susceptibility and resilience in the amygdala-hippocampal network |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634760/ https://www.ncbi.nlm.nih.gov/pubmed/37961124 http://dx.doi.org/10.1101/2023.10.23.563652 |
work_keys_str_mv | AT xiafrances neuralsignaturesofstresssusceptibilityandresilienceintheamygdalahippocampalnetwork AT fascianellivaleria neuralsignaturesofstresssusceptibilityandresilienceintheamygdalahippocampalnetwork AT vishwakarmanina neuralsignaturesofstresssusceptibilityandresilienceintheamygdalahippocampalnetwork AT ghingerfrancesgrace neuralsignaturesofstresssusceptibilityandresilienceintheamygdalahippocampalnetwork AT fusistefano neuralsignaturesofstresssusceptibilityandresilienceintheamygdalahippocampalnetwork AT kheirbekmazena neuralsignaturesofstresssusceptibilityandresilienceintheamygdalahippocampalnetwork |