Cargando…

Neural signatures of stress susceptibility and resilience in the amygdala-hippocampal network

The neural dynamics that underlie divergent anhedonic responses to stress remain unclear. Here, we identified neuronal dynamics in an amygdala-hippocampal circuit that distinguish stress resilience and susceptibility. In a reward-choice task, basolateral amygdala (BLA) activity in resilient mice sho...

Descripción completa

Detalles Bibliográficos
Autores principales: Xia, Frances, Fascianelli, Valeria, Vishwakarma, Nina, Ghinger, Frances Grace, Fusi, Stefano, Kheirbek, Mazen A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634760/
https://www.ncbi.nlm.nih.gov/pubmed/37961124
http://dx.doi.org/10.1101/2023.10.23.563652
_version_ 1785146236910698496
author Xia, Frances
Fascianelli, Valeria
Vishwakarma, Nina
Ghinger, Frances Grace
Fusi, Stefano
Kheirbek, Mazen A
author_facet Xia, Frances
Fascianelli, Valeria
Vishwakarma, Nina
Ghinger, Frances Grace
Fusi, Stefano
Kheirbek, Mazen A
author_sort Xia, Frances
collection PubMed
description The neural dynamics that underlie divergent anhedonic responses to stress remain unclear. Here, we identified neuronal dynamics in an amygdala-hippocampal circuit that distinguish stress resilience and susceptibility. In a reward-choice task, basolateral amygdala (BLA) activity in resilient mice showed enhanced discrimination of upcoming reward choices. In contrast, a rumination-like signature emerged in the BLA of susceptible mice; a linear decoder could classify the intention to switch or stay on a previously chosen reward. Spontaneous activity in the BLA of susceptible mice was higher dimensional than controls, reflecting the exploration of a larger number of distinct neural states. Manipulation of vCA1-BLA inputs rescued dysfunctional neural dynamics and anhedonia in susceptible mice, suggesting that targeting this pathway can enhance BLA circuit function and ameliorate of depression-related behaviors.
format Online
Article
Text
id pubmed-10634760
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Cold Spring Harbor Laboratory
record_format MEDLINE/PubMed
spelling pubmed-106347602023-11-13 Neural signatures of stress susceptibility and resilience in the amygdala-hippocampal network Xia, Frances Fascianelli, Valeria Vishwakarma, Nina Ghinger, Frances Grace Fusi, Stefano Kheirbek, Mazen A bioRxiv Article The neural dynamics that underlie divergent anhedonic responses to stress remain unclear. Here, we identified neuronal dynamics in an amygdala-hippocampal circuit that distinguish stress resilience and susceptibility. In a reward-choice task, basolateral amygdala (BLA) activity in resilient mice showed enhanced discrimination of upcoming reward choices. In contrast, a rumination-like signature emerged in the BLA of susceptible mice; a linear decoder could classify the intention to switch or stay on a previously chosen reward. Spontaneous activity in the BLA of susceptible mice was higher dimensional than controls, reflecting the exploration of a larger number of distinct neural states. Manipulation of vCA1-BLA inputs rescued dysfunctional neural dynamics and anhedonia in susceptible mice, suggesting that targeting this pathway can enhance BLA circuit function and ameliorate of depression-related behaviors. Cold Spring Harbor Laboratory 2023-10-23 /pmc/articles/PMC10634760/ /pubmed/37961124 http://dx.doi.org/10.1101/2023.10.23.563652 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Article
Xia, Frances
Fascianelli, Valeria
Vishwakarma, Nina
Ghinger, Frances Grace
Fusi, Stefano
Kheirbek, Mazen A
Neural signatures of stress susceptibility and resilience in the amygdala-hippocampal network
title Neural signatures of stress susceptibility and resilience in the amygdala-hippocampal network
title_full Neural signatures of stress susceptibility and resilience in the amygdala-hippocampal network
title_fullStr Neural signatures of stress susceptibility and resilience in the amygdala-hippocampal network
title_full_unstemmed Neural signatures of stress susceptibility and resilience in the amygdala-hippocampal network
title_short Neural signatures of stress susceptibility and resilience in the amygdala-hippocampal network
title_sort neural signatures of stress susceptibility and resilience in the amygdala-hippocampal network
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634760/
https://www.ncbi.nlm.nih.gov/pubmed/37961124
http://dx.doi.org/10.1101/2023.10.23.563652
work_keys_str_mv AT xiafrances neuralsignaturesofstresssusceptibilityandresilienceintheamygdalahippocampalnetwork
AT fascianellivaleria neuralsignaturesofstresssusceptibilityandresilienceintheamygdalahippocampalnetwork
AT vishwakarmanina neuralsignaturesofstresssusceptibilityandresilienceintheamygdalahippocampalnetwork
AT ghingerfrancesgrace neuralsignaturesofstresssusceptibilityandresilienceintheamygdalahippocampalnetwork
AT fusistefano neuralsignaturesofstresssusceptibilityandresilienceintheamygdalahippocampalnetwork
AT kheirbekmazena neuralsignaturesofstresssusceptibilityandresilienceintheamygdalahippocampalnetwork