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Complement C1q-dependent engulfment of alpha-synuclein induces ENS-resident macrophage exhaustion and accelerates Parkinson’s-like gut pathology

Deposition of misfolded α-synuclein (αsyn) in the enteric nervous system (ENS) is found in multiple neurodegenerative diseases. It is hypothesized that ENS synucleinopathy contributes to both the pathogenesis and non-motor morbidity in Parkinson’s Disease (PD), but the cellular and molecular mechani...

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Detalles Bibliográficos
Autores principales:	Mackie, PM, Koshy, J, Bhogade, M, Hammoor, T, Hachmeister, W, Lloyd, GM, Paterno, G, Bolen, M, Tansey, MG, Giasson, BI, Khoshbouei, H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634831/ https://www.ncbi.nlm.nih.gov/pubmed/37961460 http://dx.doi.org/10.1101/2023.10.24.563832

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