DAP12 deficiency alters microglia-oligodendrocyte communication and enhances resilience against tau toxicity

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Pathogenic tau accumulation fuels neurodegeneration in Alzheimer’s disease (AD). Enhancing aging brain’s resilience to tau pathology would lead to novel therapeutic strategies. DAP12 (DNAX-activation protein 12) is critically involved in microglial immune responses. Previous studies have showed that...

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Detalles Bibliográficos
Autores principales: Chen, Hao, Fan, Li, Guo, Qi, Wong, Man Ying, Yu, Fangmin, Foxe, Nessa, Wang, Winston, Nessim, Aviram, Carling, Gillian, Liu, Bangyan, Lopez-Lee, Chloe, Huang, Yige, Amin, Sadaf, Patel, Tark, Mok, Sue-Ann, Song, Won-min, Zhang, Bin, Ma, Qin, Fu, Hongjun, Gan, Li, Luo, Wenjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634844/
https://www.ncbi.nlm.nih.gov/pubmed/37961594
http://dx.doi.org/10.1101/2023.10.26.563970
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