A glycolytic metabolite restores DNA repair activity of polynucleotide kinase 3’-phosphatase in polyglutamine (PolyQ) diseases

We previously reported that the loss of activity of an essential DNA repair enzyme, polynucleotide kinase 3’-phosphatase (PNKP), resulted in accumulation of double strand breaks (DSB) in patient’s brain genome in Huntington’s disease (HD) and Spinocerebellar ataxia type 3 (SCA3). Here we document th...

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Detalles Bibliográficos
Autores principales: Chakraborty, Anirban, Miller, Wyatt, Huai, Weihan, Biswas, Tapan, Mohan Mandal, Santi, Bosca, Lisardo, Ghosh, Gourisankar, Hazra, Tapas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634858/
https://www.ncbi.nlm.nih.gov/pubmed/37961108
http://dx.doi.org/10.1101/2023.10.26.564220

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