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Integrating brainstem and cortical functional architectures

The brainstem is a fundamental component of the central nervous system yet it is typically excluded from in vivo human brain mapping efforts, precluding a complete understanding of how the brainstem influences cortical function. Here we use high-resolution 7 Tesla fMRI to derive a functional connect...

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Autores principales: Hansen, Justine Y., Cauzzo, Simone, Singh, Kavita, García-Gomar, María Guadalupe, Shine, James M., Bianciardi, Marta, Misic, Bratislav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634864/
https://www.ncbi.nlm.nih.gov/pubmed/37961347
http://dx.doi.org/10.1101/2023.10.26.564245
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author Hansen, Justine Y.
Cauzzo, Simone
Singh, Kavita
García-Gomar, María Guadalupe
Shine, James M.
Bianciardi, Marta
Misic, Bratislav
author_facet Hansen, Justine Y.
Cauzzo, Simone
Singh, Kavita
García-Gomar, María Guadalupe
Shine, James M.
Bianciardi, Marta
Misic, Bratislav
author_sort Hansen, Justine Y.
collection PubMed
description The brainstem is a fundamental component of the central nervous system yet it is typically excluded from in vivo human brain mapping efforts, precluding a complete understanding of how the brainstem influences cortical function. Here we use high-resolution 7 Tesla fMRI to derive a functional connectome encompassing cortex as well as 58 brainstem nuclei spanning the midbrain, pons and medulla. We identify a compact set of integrative hubs in the brainstem with widespread connectivity with cerebral cortex. Patterns of connectivity between brainstem and cerebral cortex manifest as multiple emergent phenomena including neurophysiological oscillatory rhythms, patterns of cognitive functional specialization, and the unimodal-transmodal functional hierarchy. This persistent alignment between cortical functional topographies and brainstem nuclei is shaped by the spatial arrangement of multiple neurotransmitter receptors and transporters. We replicate all findings using 3 Tesla data from the same participants. Collectively, we find that multiple organizational features of cortical activity can be traced back to the brainstem.
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spelling pubmed-106348642023-11-13 Integrating brainstem and cortical functional architectures Hansen, Justine Y. Cauzzo, Simone Singh, Kavita García-Gomar, María Guadalupe Shine, James M. Bianciardi, Marta Misic, Bratislav bioRxiv Article The brainstem is a fundamental component of the central nervous system yet it is typically excluded from in vivo human brain mapping efforts, precluding a complete understanding of how the brainstem influences cortical function. Here we use high-resolution 7 Tesla fMRI to derive a functional connectome encompassing cortex as well as 58 brainstem nuclei spanning the midbrain, pons and medulla. We identify a compact set of integrative hubs in the brainstem with widespread connectivity with cerebral cortex. Patterns of connectivity between brainstem and cerebral cortex manifest as multiple emergent phenomena including neurophysiological oscillatory rhythms, patterns of cognitive functional specialization, and the unimodal-transmodal functional hierarchy. This persistent alignment between cortical functional topographies and brainstem nuclei is shaped by the spatial arrangement of multiple neurotransmitter receptors and transporters. We replicate all findings using 3 Tesla data from the same participants. Collectively, we find that multiple organizational features of cortical activity can be traced back to the brainstem. Cold Spring Harbor Laboratory 2023-10-26 /pmc/articles/PMC10634864/ /pubmed/37961347 http://dx.doi.org/10.1101/2023.10.26.564245 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
spellingShingle Article
Hansen, Justine Y.
Cauzzo, Simone
Singh, Kavita
García-Gomar, María Guadalupe
Shine, James M.
Bianciardi, Marta
Misic, Bratislav
Integrating brainstem and cortical functional architectures
title Integrating brainstem and cortical functional architectures
title_full Integrating brainstem and cortical functional architectures
title_fullStr Integrating brainstem and cortical functional architectures
title_full_unstemmed Integrating brainstem and cortical functional architectures
title_short Integrating brainstem and cortical functional architectures
title_sort integrating brainstem and cortical functional architectures
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634864/
https://www.ncbi.nlm.nih.gov/pubmed/37961347
http://dx.doi.org/10.1101/2023.10.26.564245
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