How a disordered linker in the Polycomb protein Polyhomeotic tunes phase separation and oligomerization

The Polycomb Group (PcG) complex PRC1 represses transcription, forms condensates in cells, and modifies chromatin architecture. These processes are connected through the essential, polymerizing Sterile Alpha Motif (SAM) present in the PRC1 subunit Polyhomeotic (Ph). In vitro, Ph SAM drives formation...

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Detalles Bibliográficos
Autores principales: Gemeinhardt, Tim M., Regy, Roshan M., Mendiola, Andrea J., Ledterman, Heather J., Henrickson, Amy, Phan, Tien M., Kim, Young C., Demeler, Borries, Kim, Chongwoo A., Mittal, Jeetain, Francis, Nicole J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634872/
https://www.ncbi.nlm.nih.gov/pubmed/37961422
http://dx.doi.org/10.1101/2023.10.26.564264

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634872/
https://www.ncbi.nlm.nih.gov/pubmed/37961422
http://dx.doi.org/10.1101/2023.10.26.564264

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