Cargando…

How a disordered linker in the Polycomb protein Polyhomeotic tunes phase separation and oligomerization

The Polycomb Group (PcG) complex PRC1 represses transcription, forms condensates in cells, and modifies chromatin architecture. These processes are connected through the essential, polymerizing Sterile Alpha Motif (SAM) present in the PRC1 subunit Polyhomeotic (Ph). In vitro, Ph SAM drives formation...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gemeinhardt, Tim M., Regy, Roshan M., Mendiola, Andrea J., Ledterman, Heather J., Henrickson, Amy, Phan, Tien M., Kim, Young C., Demeler, Borries, Kim, Chongwoo A., Mittal, Jeetain, Francis, Nicole J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634872/ https://www.ncbi.nlm.nih.gov/pubmed/37961422 http://dx.doi.org/10.1101/2023.10.26.564264

Ejemplares similares

Phase separation by the polyhomeotic sterile alpha motif compartmentalizes Polycomb Group proteins and enhances their activity
por: Seif, Elias, et al.
Publicado: (2020)

Mutations in the Polycomb Group Gene polyhomeotic Lead to Epithelial Instability in both the Ovary and Wing Imaginal Disc in Drosophila
por: Gandille, Pierre, et al.
Publicado: (2010)

Structure-function studies reveal ComEA contains an oligomerization domain essential for transformation in gram-positive bacteria
por: Ahmed, Ishtiyaq, et al.
Publicado: (2022)

Sequence dependent phase separation of protein-polynucleotide mixtures elucidated using molecular simulations
por: Regy, Roshan Mammen, et al.
Publicado: (2020)

Regulation of Polyhomeotic Condensates by Intrinsically Disordered Sequences That Affect Chromatin Binding
por: Kapur, Ibani, et al.
Publicado: (2022)

Moving analytical ultracentrifugation software to a good manufacturing practices (GMP) environment
por: Savelyev, Alexey, et al.
Publicado: (2020)

Nanoscale Structure Determination of Murray Valley Encephalitis and Powassan Virus Non-Coding RNAs
por: Mrozowich, Tyler, et al.
Publicado: (2020)

Disruption of polyhomeotic polymerization decreases nucleosome occupancy and alters genome accessibility
por: Amin, Adfar, et al.
Publicado: (2023)

Purification and characterization of inorganic pyrophosphatase for in vitro RNA transcription
por: Tersteeg, Scott, et al.
Publicado: (2022)

Interplay between charge distribution and DNA in shaping HP1 paralog phase separation and localization
por: Phan, Tien M., et al.
Publicado: (2023)

A new mode of SAM domain mediated oligomerization observed in the CASKIN2 neuronal scaffolding protein
por: Smirnova, Ekaterina, et al.
Publicado: (2016)

Contribution of oligomerization to the anti-HIV-1 properties of SAMHD1
por: Brandariz-Nuñez, Alberto, et al.
Publicado: (2013)

Measuring molecular interactions in solution using multi-wavelength analytical ultracentrifugation: combining spectral analysis with hydrodynamics
por: Demeler, Borries
Publicado: (2019)

BMI1 regulates PRC1 architecture and activity through homo- and hetero-oligomerization
por: Gray, Felicia, et al.
Publicado: (2016)

Reversible Kinetic Trapping of FUS Biomolecular Condensates
por: Chatterjee, Sayantan, et al.
Publicado: (2021)

A conserved oligomerization domain in the disordered linker of coronavirus nucleocapsid proteins
por: Zhao, Huaying, et al.
Publicado: (2023)

Hsp70 Oligomerization Is Mediated by an Interaction between the Interdomain Linker and the Substrate-Binding Domain
por: Aprile, Francesco A., et al.
Publicado: (2013)

Assembly Mechanism of the Sixty-Subunit Nanoparticles via Interaction of RNA with the Reengineered Protein Connector of phi29 DNA-Packaging Motor
por: Xiao, Feng, et al.
Publicado: (2010)

Sulforaphane inhibits self-renewal of lung cancer stem cells through the modulation of sonic Hedgehog signaling pathway and polyhomeotic homolog 3
por: Wang, Fanping, et al.
Publicado: (2021)

Synaptotagmin 1 oligomerization via the juxtamembrane linker regulates spontaneous and evoked neurotransmitter release
por: Courtney, Kevin C., et al.
Publicado: (2021)

Polymorphism of Oligomers of a Peptide from β-Amyloid
por: Pham, Johnny D., et al.
Publicado: (2014)

Biophysical characterisation of human LincRNA-p21 sense and antisense Alu inverted repeats
por: D’Souza, Michael H, et al.
Publicado: (2022)

Human DDX17 Unwinds Rift Valley Fever Virus Non-Coding RNAs
por: Nelson, Corey R., et al.
Publicado: (2020)

Molecular interactions underlying the phase separation of HP1α: role of phosphorylation, ligand and nucleic acid binding
por: Her, Cheenou, et al.
Publicado: (2022)

Construction of porous cationic frameworks by crosslinking polyhedral oligomeric silsesquioxane units with N-heterocyclic linkers
por: Chen, Guojian, et al.
Publicado: (2015)

Structure and Enzymatic Activity of an Intellectual Disability-Associated Ornithine Decarboxylase Variant, G84R
por: Zhou, X. Edward, et al.
Publicado: (2022)

The Interdomain Linker of AAV-2 Rep68 Is an Integral Part of Its Oligomerization Domain: Role of a Conserved SF3 Helicase Residue in Oligomerization
por: Zarate-Perez, Francisco, et al.
Publicado: (2012)

Investigating RNA–RNA interactions through computational and biophysical analysis
por: Mrozowich, Tyler, et al.
Publicado: (2023)

Expression and Characterization of Intein-Cyclized Trimer of Staphylococcus aureus Protein A Domain Z
por: Nandy, Suman, et al.
Publicado: (2023)

A coarse-grained DNA model to study protein-DNA interactions and liquid-liquid phase separation
por: Kapoor, Utkarsh, et al.
Publicado: (2023)

The BRPF1 bromodomain is a molecular reader of di-acetyllysine
por: Obi, Juliet O., et al.
Publicado: (2020)

Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism
por: Horne, Christopher R., et al.
Publicado: (2021)

A linker protein from a red-type pyrenoid phase separates with Rubisco via oligomerizing sticker motifs
por: Oh, Zhen Guo, et al.
Publicado: (2023)

Formation of a Polycomb-Domain in the Absence of Strong Polycomb Response Elements
por: De, Sandip, et al.
Publicado: (2016)

Oligomeric (Salen)Mn(III) Complexes Featuring Tartrate Linkers Immobilized over Layered Double Hydroxide for Catalytically Asymmetric Epoxidation of Unfunctionalized Olefins
por: Jia, Yihong, et al.
Publicado: (2020)

Disorder in Cholesterol-Binding Functionality of CRAC Peptides: A Molecular Dynamics Study
por: Miller, Cayla M., et al.
Publicado: (2014)

Correction: Characterization of the Interaction between the Cohesin Subunits Rad21 and SA1/2
por: Zhang, Nenggang, et al.
Publicado: (2013)

Divergence of multimodular polyketide synthases revealed by a didomain structure
por: Zheng, Jianting, et al.
Publicado: (2012)

Characterization of the Interaction between the Cohesin Subunits Rad21 and SA1/2
por: Zhang, Nenggang, et al.
Publicado: (2013)

Structural and functional characterisation of the entry point to pyocyanin biosynthesis in Pseudomonas aeruginosa defines a new 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase subclass
por: Sterritt, Oliver W., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_afioi0eosiaufpbetkn7cg73i1