ATR promotes mTORC1 activation via de novo cholesterol synthesis in p16-low cancer cells

DNA damage and cellular metabolism are intricately linked with bidirectional feedback. Two of the main effectors of the DNA damage response and control of cellular metabolism are ATR and mTORC1, respectively. Prior work has placed ATR upstream of mTORC1 during replication stress, yet the direct mech...

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Detalles Bibliográficos
Autores principales: Tangudu, Naveen Kumar, Huang, Zhentai, Fang, Richard, Buj, Raquel, Uboveja, Apoorva, Cole, Aidan R., Happe, Cassandra, Sun, Mai, Gelhaus, Stacy L., MacDonald, Matthew L., Hempel, Nadine, Snyder, Nathaniel W., Aird, Katherine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634888/
https://www.ncbi.nlm.nih.gov/pubmed/37961201
http://dx.doi.org/10.1101/2023.10.27.564195

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