Dysregulated neuroimmune interactions and sustained type I interferon signaling after human immunodeficiency virus type 1 infection of human iPSC derived microglia and cerebral organoids

Human immunodeficiency virus type-1 (HIV-1) associated neurocognitive disorder (HAND) affects up to half of HIV-1 positive patients with long term neurological consequences, including dementia. There are no effective therapeutics for HAND because the pathophysiology of HIV-1 induced glial and neuron...

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Detalles Bibliográficos
Autores principales: Boreland, Andrew J., Stillitano, Alessandro C., Lin, Hsin-Ching, Abbo, Yara, Hart, Ronald P., Jiang, Peng, Pang, Zhiping P., Rabson, Arnold B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634901/
https://www.ncbi.nlm.nih.gov/pubmed/37961371
http://dx.doi.org/10.1101/2023.10.25.563950

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