Human iPSC-derived microglia sense and dampen hyperexcitability of cortical neurons carrying the epilepsy-associated SCN2A-L1342P mutation

Neuronal hyperexcitability is a hallmark of seizures. It has been recently shown in rodent models of seizures that microglia, the brain’s resident immune cells, can respond to and modulate neuronal excitability. However, how human microglia interacts with human neurons to regulate hyperexcitability...

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Detalles Bibliográficos
Autores principales: Que, Zhefu, Olivero-Acosta, Maria I., Chen, Ian, Zhang, Jingliang, Wettschurack, Kyle, Wu, Jiaxiang, Xiao, Tiange, Otterbacher, C. Max, Wang, Muhan, Harlow, Hope, Cui, Ningren, Chen, Xiaoling, Deming, Brody, Halurkar, Manasi, Zhao, Yuanrui, Rochet, Jean-Christophe, Xu, Ranjie, Brewster, Amy L., Wu, Long-jun, Yuan, Chongli, Skarnes, William C., Yang, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634902/
https://www.ncbi.nlm.nih.gov/pubmed/37961213
http://dx.doi.org/10.1101/2023.10.26.563426

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