Molecular definition of distinct active zone protein machineries for Ca(2+) channel clustering and synaptic vesicle priming

Action potentials trigger neurotransmitter release with minimal delay. Active zones mediate this temporal precision by co-organizing primed vesicles with Ca(V)2 Ca(2+) channels. The presumed model is that scaffolding proteins directly tether primed vesicles to Ca(V)2s. We find that Ca(V)2 clustering...

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Detalles Bibliográficos
Autores principales: Emperador-Melero, Javier, Andersen, Jonathan W., Metzbower, Sarah R., Levy, Aaron D., Dharmasri, Poorna A., de Nola, Giovanni, Blanpied, Thomas A., Kaeser, Pascal S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634917/
https://www.ncbi.nlm.nih.gov/pubmed/37961089
http://dx.doi.org/10.1101/2023.10.27.564439

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