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Excessive cortical beta oscillations are associated with slow-wave sleep dysfunction in mild parkinsonism

Increasing evidence associates slow-wave sleep (SWS) dysfunction with neurodegeneration. Using a within-subject design in the nonhuman primate model of Parkinson’s disease (PD), we found that reduced SWS quantity in mild parkinsonism was accompanied by elevated beta and reduced delta power during SW...

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Detalles Bibliográficos
Autores principales: Verma, Ajay K., Nandakumar, Bharadwaj, Acedillo, Kit, Yu, Ying, Marshall, Ethan, Schneck, David, Fiecas, Mark, Wang, Jing, MacKinnon, Colum D., Howell, Michael J., Vitek, Jerrold L., Johnson, Luke A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634920/
https://www.ncbi.nlm.nih.gov/pubmed/37961389
http://dx.doi.org/10.1101/2023.10.28.564524
Descripción
Sumario:Increasing evidence associates slow-wave sleep (SWS) dysfunction with neurodegeneration. Using a within-subject design in the nonhuman primate model of Parkinson’s disease (PD), we found that reduced SWS quantity in mild parkinsonism was accompanied by elevated beta and reduced delta power during SWS in the motor cortex. Our findings support excessive beta oscillations as a mechanism for SWS dysfunction and will inform development of neuromodulation therapies for enhancing SWS in PD.